<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18776

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPQAAPGVGAPFSQASAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPSAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLRLPFMPTWGCGGPPQGTVGASGATGQPQPQGTTQAPPGAPQGPPGAAPGQPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPSRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length492
PositionUnknown
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.05
Grand average of hydropathy-0.303
Instability index60.16
Isoelectric point9.47
Molecular weight51127.25
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.08|      27|      27|     399|     425|       1
---------------------------------------------------------------------------
   85-  107 (33.98/ 6.15)	QPSLVSTVAPG.PGLAP.SAQPGAP..
  353-  376 (46.38/11.81)	QG..TTQAPPGAPQ.GPPGAAPGQPPP
  409-  434 (50.73/13.79)	QASLHHLQPPGAPALLPPPHQ.GLGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.02|      22|      70|     310|     337|       2
---------------------------------------------------------------------------
   46-   71 (35.46/ 7.81)	YFN.GG...PP......QAAPGvgapfSQA..SAPPLP
  297-  329 (29.91/14.65)	QRGmGGqqaPPGpiledQARPS.....QNL..RLPFMP
  442-  461 (31.65/ 6.12)	H....P...PPA.....QSWPA.....Q.LpsRAPLPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.63|      15|      31|     114|     128|       4
---------------------------------------------------------------------------
  114-  128 (28.63/13.96)	APGGV....SGPSPAQLGA
  143-  161 (23.00/ 9.61)	AWSGVlewqEKPKPASVDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     206|     229|       5
---------------------------------------------------------------------------
  206-  229 (34.11/34.89)	LFrnSRMVQF.HFTNKDLESLKGLY
  235-  257 (37.50/29.74)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      15|      24|     164|     178|       6
---------------------------------------------------------------------------
  164-  178 (28.29/19.51)	KLTRSL.PCQVYVNHG
  189-  204 (21.42/12.79)	KLIMQLiPQQLLTTLG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18776 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQ
2) LRLPFMPTWGCGGPPQGTVGASGATGQPQPQGTTQAPPGAPQGPPGAAPGQPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPSRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
3) PQAAPGVGAPFSQASAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPSAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
286
323
52
321
490
132










Molecular Recognition Features






MoRF SequenceStartStop




NANANA