<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18771

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGAPFSQASAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPSAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTTQAPPGAPQGPPGAAPGQPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPSRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length533
PositionUnknown
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.05
Grand average of hydropathy-0.323
Instability index59.08
Isoelectric point9.40
Molecular weight55274.72
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18771
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     303.79|      47|      48|     397|     443|       1
---------------------------------------------------------------------------
   96-  131 (43.51/ 6.56)	......LQQAAPGvgapfsqASAPP.LPPG......PPG.AP....K.....PPPA.............SQP
  132-  185 (58.20/11.80)	SLVSTVAPGPGLA.......PSAQPGAPSM......AGTVAPGgvsG.....PSPAqlgaPALGGQQSVSNK
  397-  430 (69.69/15.90)	....................TQAPPGAPQG......PPGAAPG...Q.....PPPG....PILRPQNPGANP
  431-  475 (70.40/16.15)	QLRSLLLNPPPPQ.......TGVPP..PQAslhhlqPPGAPAL...L.....PPP.........HQGLG.QP
  476-  521 (61.99/13.15)	QLGPPLLHPPPAQ....swpAQLPSRAPL............PG...QmllsgGPRG....PV..PQ.PGLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.68|      39|      41|     311|     351|       2
---------------------------------------------------------------------------
  311-  351 (66.20/31.27)	GLIPY..DQSGFVNGIRQVitNHKQVQQQKLEQQRGMGGQQAP
  353-  393 (67.48/27.70)	GLGPIleDQARPSQNLLQL..RPPQPQPQGTVGASGATGQPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     251|     274|       3
---------------------------------------------------------------------------
  251-  274 (34.11/27.20)	LFrnSRMVQF.HFTNKDLESLKGLY
  280-  302 (37.50/23.17)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.83|      30|      57|       2|      32|       4
---------------------------------------------------------------------------
    2-   32 (48.90/39.03)	VPGSEGPARAGGLVAdVVFVIEGTANLGPYF
   61-   90 (50.93/35.19)	VPGNLSAAQVAAQNA.VEAAKNQKAGLGPRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      15|      23|     209|     223|       6
---------------------------------------------------------------------------
  209-  223 (28.29/16.90)	KLTRSL.PCQVYVNHG
  234-  249 (21.42/11.07)	KLIMQLiPQQLLTTLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18771 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKQVQQQKLEQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGATGQPQPQGTTQAPPGAPQGPPGAAPGQPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPSRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
2) VEAAKNQKAGLGPRFSPITPLQQAAPGVGAPFSQASAPPLPPGPPGAPKPPPASQPSLVSTVAPGPGLAPSAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
331
76
531
177










Molecular Recognition Features






MoRF SequenceStartStop




NANANA