<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18768

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGVTLKNTFPFLFPVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSRDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGILVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYTQPVPHSQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVASKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSSSKSHHSHSSSSSSSSSASTSSKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGCDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASASSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMSASTNSSSHAMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSADSSKKASESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRAQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQSLSITSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1565
PositionMiddle
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.05
Grand average of hydropathy-0.667
Instability index54.51
Isoelectric point8.96
Molecular weight166753.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18768
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     431.54|      49|      50|     961|    1009|       1
---------------------------------------------------------------------------
  652-  696 (39.05/ 7.87)	.NSSSGSPR....ME.MC.SG.S.NKTKKK..K..SSRLP......P....D.....KPKHQTEDDFQRELFS
  752-  800 (35.02/ 6.09)	SSSDSIGPDvtdiLS.DI.AE.EASKLPST.....SDDCP......PigtpV.....R.....DSSSSGHSQS
  961- 1009 (87.40/29.14)	SNSTLSGPG....LD.SK.PG.KRSRTPSNDGK..SKDKP......P....K.....RKKADTEGKSPSHSSS
 1016- 1065 (41.04/ 8.74)	PTST....G.....G.SKsPG.SSGRSQTPPGV..ATPPI......P....KitiqiPKGTVMVGKPSSHSQY
 1070- 1113 (51.62/13.40)	SVSSSSSKS....HH.SH.SS.SSSSSSSASTS..SKMKS......S....K..........SEGSSSSKLSS
 1167- 1213 (48.17/11.88)	.NPSLSKPN....IS....P..SHSRPPGGCDKlaSPMKP......V....P.....GTPPSSKAKSPISSGS
 1214- 1260 (48.26/11.92)	GGSHMSGTS.......SS.SGmKSSSGLGSSGS..LSQKT......P....P.....SSNSCTASAS.SFSSS
 1347- 1387 (36.43/ 6.72)	SKVSTSGSS....ADsSK.KA.SESKNVGSTGV..AKIII......S....K.....H.....DGGSP....S
 1390- 1437 (44.54/10.28)	AKVTLQKPG....ES.SG.EG.LRAQMAS..SK..NYGSPlisgstP....K.....HER....G.SPSHSKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     207.60|      52|      65|     529|     585|       2
---------------------------------------------------------------------------
  529-  585 (81.84/48.12)	GyGMTTGNNPMSgtTTPTNTFPgGPI......TTLFNMSMS.IKDRHESvGHGED.FSKV.SQNPI
  596-  648 (69.08/27.46)	G.GSTIGSSP....TPPHHTPP..PVssmagnTKNHPMLMNlLKD...N..PAQD.FSTLyGSSPL
  830-  871 (56.68/20.92)	........SPSS..DSPTNHF..FPD......GVDFNPDL..LNSQSQS.GFGEEyFDES.SQS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     267.09|      51|      51|     313|     363|       3
---------------------------------------------------------------------------
  228-  254 (27.59/14.43)	....................................PVPRSLGM...............NA...SVTIEGTSAMY...KL.PIAP
  257-  310 (54.30/38.07)	MgSHPVdnkWTPSFSSITsansvdlpaCFFL.KFPQPIPVSRA.................F...VQKL...QNCT.......GIP
  313-  363 (93.46/72.75)	E.TQPT...YVPLYELIT.........QFELSRDPDPIPLNHNM...............RF...YAALPGQQHCY...FLNKDAP
  366-  417 (57.34/40.77)	D.GRSL...QGILVSKIT..........FQ...HPGRVPLILNL..............iRHqvaYNTLIGS..CVkrtILKEDSP
  423-  471 (34.40/20.45)	E.V.......CPLSE..S.........RFSISFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.55|      13|      22|     872|     884|       4
---------------------------------------------------------------------------
  872-  884 (25.98/18.43)	GDNDD..FKGFA.SQA
  895-  908 (18.07/ 9.80)	GDNGEtkFKG.N.SQA
  924-  937 (16.50/ 8.09)	GPADL..MEHHSgSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.40|      37|     148|    1114|    1162|       5
---------------------------------------------------------------------------
 1114- 1151 (60.86/26.04)	SMYSSQGSSGSSQSKNSSQSGgKPGSSPIT...KHGLSSGS
 1263- 1302 (56.54/12.87)	SMSSSQNQHGSSKGKSPSRNK.KPSLTAVIdklKHGVVTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.85|      11|      25|    1304|    1316|       6
---------------------------------------------------------------------------
 1304- 1316 (16.30/16.86)	GGEdpMDGQMSAS
 1332- 1342 (20.55/11.62)	GGE..FQGKREKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.52|      12|      15|    1479|    1490|      17
---------------------------------------------------------------------------
 1479- 1490 (19.60/11.90)	EKHKKHKKEKKK
 1497- 1508 (19.91/12.21)	DRDRDKDRDKKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18768 with Med1 domain of Kingdom Metazoa
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