<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18767
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSRDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGILVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGEPGLNCFTLPENQGALHFSTGWRRRSRIIQAWDTSLLSRCTHSPVSKDGKDMKSTSTTFCWCLMYS |
Length | 613 |
Position | Middle |
Organism | Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes>
Indriidae> Propithecus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.207 |
Instability index | 54.51 |
Isoelectric point | 8.33 |
Molecular weight | 68342.13 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18767
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 214.88| 48| 49| 152| 199| 2
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152- 199 (81.98/60.60) KHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQ.DLSKMAIMYWKATNAGP
202- 248 (69.01/49.71) KILHGSVG.YLT..........PrsGGHLMNIKYYASPSDLLD.DKTTSPIILHE..NNVP
257- 312 (63.89/45.42) VTIEGTSAMYKLpiaplimgshP..VDNKW.TPSFSSITSANSvDLP..ACFFLKFPQPIP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 106.15| 30| 108| 425| 454| 3
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425- 454 (51.14/26.79) VKRTILKEDSPGLLQFEVCPLSESRFSISF
536- 565 (55.01/29.31) VKKNLPPASSPGEPGLNCFTLPENQGALHF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.34| 14| 56| 512| 528| 5
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512- 528 (19.63/20.68) RRKAETIQA.DTpalSLI
570- 584 (20.71/11.91) RRRSRIIQAwDT...SLL
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