<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18766

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSRDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGILVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYTQPVPHSQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVASKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSSSKSHHSHSSSSSSSSSASTSSKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGCDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASASSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMSASTNSSSHAMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSADSSKKASESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRAQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQSLSITSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1583
PositionMiddle
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.04
Grand average of hydropathy-0.675
Instability index54.87
Isoelectric point8.87
Molecular weight168730.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18766
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     442.25|      49|      50|     979|    1027|       1
---------------------------------------------------------------------------
  670-  714 (43.02/11.51)	.....NSSSGS..PR....MEMC.SG.S.NKTKKK..K..SSRLP......P....D.....KPKHQTEDDFQRELFS
  770-  818 (37.49/ 8.73)	S....SSDSIG..PDvtdiLSDI.AE.EASKLPST.....SDDCP......PigtpV.....R.....DSSSSGHSQS
  979- 1027 (88.66/34.47)	S....NSTLSG..PG....LDSK.PG.KRSRTPSNDGK..SKDKP......P....K.....RKKADTEGKSPSHSSS
 1034- 1083 (43.54/11.77)	P....TST......G.....GSKsPG.SSGRSQTPPGV..ATPPI......P....KitiqiPKGTVMVGKPSSHSQY
 1088- 1131 (53.26/16.66)	S....VSSSSS..KS....HHSH.SS.SSSSSSSASTS..SKMKS......S....K..........SEGSSSSKLSS
 1142- 1182 (35.48/ 7.72)	SsqskNSSQSGgkPG......SS.PI.TKHGLSSGSSS..TKMKP.....................Q..GK.PS.S..
 1185- 1231 (51.09/15.57)	.....NPSLSK..PN....IS...P..SHSRPPGGCDKlaSPMKP......V....P.....GTPPSSKAKSPISSGS
 1232- 1278 (50.27/15.16)	G....GSHMSG..TS......SS.SGmKSSSGLGSSGS..LSQKT......P....P.....SSNSCTASAS.SFSSS
 1411- 1455 (39.45/ 9.72)	.......TLQK..PG....ESSG.EG.LRAQMAS..SK..NYGSPlisgstP....K.....HER....G.SPSHSKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.74|      35|      50|    1282|    1324|       2
---------------------------------------------------------------------------
 1301- 1355 (42.33/35.43)	KKPsltaviDKLKHGVVTSGPGGEdpmdgqMSASTNssshamssKHNMSG.......GEFQG
 1358- 1405 (38.41/14.92)	EKS......DKDKSKVSTSGSSAD..sskkASESKN......vgSTGVAKiiiskhdGGSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     229.85|      50|      50|     150|     199|       3
---------------------------------------------------------------------------
  146-  182 (50.59/31.11)	.............NFDE......FSKHL..KGLV.NLYNL..........P..GDNKLKTK.MYLALQSLEQ
  183-  233 (74.98/50.35)	DLSKMAIMYWKATNAGP......LDKIL..HGSV.G.YLT..........PrsGGHLMNIK.YYASPSDLLD
  234-  296 (56.16/35.51)	DKTTSPIILHE..NNVPrslgmnASVTI..EGTS.AMYKLpiaplimgshP..VDNKW.TP.SFSSITSANS
  298-  342 (48.12/29.17)	DLP..ACFFLKFPQPIP...........vsRAFVqKLQNC..........T..GIPLFETQpTYVPLYEL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.04|      33|      51|     343|     381|       4
---------------------------------------------------------------------------
  343-  381 (52.86/50.71)	ITqFElsrDPDPIPLNHNM.RF...YAALPGQqhCY...FLNKDAP
  396-  435 (48.18/28.00)	IT.FQ...HPGRVPLILNLiRHqvaYNTLIGS..CVkrtILKEDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.12|      21|      42|     602|     622|       5
---------------------------------------------------------------------------
  602-  622 (33.10/13.63)	PILTSLLQITGNGGSTI.GSSP
  624-  643 (36.59/15.93)	PPHHTPPPVSSMAGNT..KNHP
  644-  665 (27.42/ 9.88)	MLMNLLKDNPAQDFSTLyGSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     179.35|      42|     100|     838|     879|       6
---------------------------------------------------------------------------
  838-  879 (79.55/49.62)	PADLIADAAGSP..SSDSPTNHF....FPDGVDFNPDLLNSQSQ....SGFG
  884-  905 (23.12/ 7.76)	......D....E..SSQSGDNDD....F.KG..FASQALNT...........
  907-  942 (28.17/11.50)	.........GVPmlGGDNGETKFkgnsQADTVDFS...IISVAS....KALG
  943-  977 (48.51/26.59)	PADLMEHHSG.....SQSP...L....LATG.....DLGKEKTQkrvkEGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.03|      17|      20|     541|     558|       7
---------------------------------------------------------------------------
  541-  558 (30.58/17.54)	PPASSPGYGMTTGNNpMS
  563-  579 (34.45/15.45)	PTNTFPGGPITTLFN.MS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.78|      27|      70|    1460|    1494|      10
---------------------------------------------------------------------------
 1460- 1486 (45.33/33.83)	PQNLDSESESGSSIAEKSYQNSPSSDD
 1517- 1543 (47.45/18.79)	DRDKDRDKKKSHSIKPENWSKSPISSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18766 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSSSKSHHSHSSSSSSSSSASTSSKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGCDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASASSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMSASTNSSSHAMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSADSSKKASESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRAQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQSLSITSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
2) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
3) LFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYTQPVPHSQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFN
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQAD
937
538
575
869
1583
571
866
927










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFDE
2) IKAKVTLQK
3) IRPLPEYSTEKHKKHKKEKKKVKDKDR
4) KITIQIPK
5) KPSLTAVIDKLKHGV
6) RLSPDFMIGEEDDDLMD
7) VAKIIISKH
878
1406
1488
1062
1302
1561
1391
885
1414
1514
1069
1316
1577
1399