<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18766
| Description |
Mediator of RNA polymerase II transcription subunit 1 |
| Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNIKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSRDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGILVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYTQPVPHSQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVASKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSSSKSHHSHSSSSSSSSSASTSSKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGCDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASASSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMSASTNSSSHAMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSADSSKKASESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRAQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPENWSKSPISSDQSLSITSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
| Length | 1583 |
| Position | Middle |
| Organism | Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes>
Indriidae> Propithecus.
|
| Aromaticity | 0.04 |
| Grand average of hydropathy | -0.675 |
| Instability index | 54.87 |
| Isoelectric point | 8.87 |
| Molecular weight | 168730.41 |
| Publications | |
Function
| Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
|
| GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleolus GO:0005730 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
| GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl
estrogen receptor binding GO:0030331 IEA:Ensembl
LBD domain binding GO:0050693 IEA:Ensembl
nuclear receptor coactivator activity GO:0030374 IEA:Ensembl
peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl
promoter-specific chromatin binding GO:1990841 IEA:Ensembl
protein-containing complex binding GO:0044877 IEA:Ensembl
retinoic acid receptor binding GO:0042974 IEA:Ensembl
thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription corepressor activity GO:0003714 IEA:Ensembl
vitamin D receptor binding GO:0042809 IEA:Ensembl
|
| GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl
angiogenesis GO:0001525 IEA:Ensembl
animal organ regeneration GO:0031100 IEA:Ensembl
brain development GO:0007420 IEA:Ensembl
cell morphogenesis GO:0000902 IEA:Ensembl
cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl
cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl
cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl
embryonic heart tube development GO:0035050 IEA:Ensembl
embryonic hemopoiesis GO:0035162 IEA:Ensembl
embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl
embryonic placenta development GO:0001892 IEA:Ensembl
enucleate erythrocyte development GO:0048822 IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl
fat cell differentiation GO:0045444 IEA:Ensembl
intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl
keratinocyte differentiation GO:0030216 IEA:Ensembl
lactation GO:0007595 IEA:Ensembl
lens development in camera-type eye GO:0002088 IEA:Ensembl
liver development GO:0001889 IEA:Ensembl
mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl
mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl
megakaryocyte development GO:0035855 IEA:Ensembl
monocyte differentiation GO:0030224 IEA:Ensembl
mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl
negative regulation of apoptotic process GO:0043066 IEA:Ensembl
negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl
negative regulation of neuron differentiation GO:0045665 IEA:Ensembl
negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl
positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl
positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl
positive regulation of gene expression GO:0010628 IEA:Ensembl
positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl
positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
protein import into nucleus GO:0006606 IEA:Ensembl
regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl
retinal pigment epithelium development GO:0003406 IEA:Ensembl
thyroid hormone generation GO:0006590 IEA:Ensembl
thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl
ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl
|
Interaction
Repeat regions
| Repeats |
>MDP18766
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
9| 442.25| 49| 50| 979| 1027| 1
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670- 714 (43.02/11.51) .....NSSSGS..PR....MEMC.SG.S.NKTKKK..K..SSRLP......P....D.....KPKHQTEDDFQRELFS
770- 818 (37.49/ 8.73) S....SSDSIG..PDvtdiLSDI.AE.EASKLPST.....SDDCP......PigtpV.....R.....DSSSSGHSQS
979- 1027 (88.66/34.47) S....NSTLSG..PG....LDSK.PG.KRSRTPSNDGK..SKDKP......P....K.....RKKADTEGKSPSHSSS
1034- 1083 (43.54/11.77) P....TST......G.....GSKsPG.SSGRSQTPPGV..ATPPI......P....KitiqiPKGTVMVGKPSSHSQY
1088- 1131 (53.26/16.66) S....VSSSSS..KS....HHSH.SS.SSSSSSSASTS..SKMKS......S....K..........SEGSSSSKLSS
1142- 1182 (35.48/ 7.72) SsqskNSSQSGgkPG......SS.PI.TKHGLSSGSSS..TKMKP.....................Q..GK.PS.S..
1185- 1231 (51.09/15.57) .....NPSLSK..PN....IS...P..SHSRPPGGCDKlaSPMKP......V....P.....GTPPSSKAKSPISSGS
1232- 1278 (50.27/15.16) G....GSHMSG..TS......SS.SGmKSSSGLGSSGS..LSQKT......P....P.....SSNSCTASAS.SFSSS
1411- 1455 (39.45/ 9.72) .......TLQK..PG....ESSG.EG.LRAQMAS..SK..NYGSPlisgstP....K.....HER....G.SPSHSKS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 80.74| 35| 50| 1282| 1324| 2
---------------------------------------------------------------------------
1301- 1355 (42.33/35.43) KKPsltaviDKLKHGVVTSGPGGEdpmdgqMSASTNssshamssKHNMSG.......GEFQG
1358- 1405 (38.41/14.92) EKS......DKDKSKVSTSGSSAD..sskkASESKN......vgSTGVAKiiiskhdGGSPS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 229.85| 50| 50| 150| 199| 3
---------------------------------------------------------------------------
146- 182 (50.59/31.11) .............NFDE......FSKHL..KGLV.NLYNL..........P..GDNKLKTK.MYLALQSLEQ
183- 233 (74.98/50.35) DLSKMAIMYWKATNAGP......LDKIL..HGSV.G.YLT..........PrsGGHLMNIK.YYASPSDLLD
234- 296 (56.16/35.51) DKTTSPIILHE..NNVPrslgmnASVTI..EGTS.AMYKLpiaplimgshP..VDNKW.TP.SFSSITSANS
298- 342 (48.12/29.17) DLP..ACFFLKFPQPIP...........vsRAFVqKLQNC..........T..GIPLFETQpTYVPLYEL..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 101.04| 33| 51| 343| 381| 4
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343- 381 (52.86/50.71) ITqFElsrDPDPIPLNHNM.RF...YAALPGQqhCY...FLNKDAP
396- 435 (48.18/28.00) IT.FQ...HPGRVPLILNLiRHqvaYNTLIGS..CVkrtILKEDSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 97.12| 21| 42| 602| 622| 5
---------------------------------------------------------------------------
602- 622 (33.10/13.63) PILTSLLQITGNGGSTI.GSSP
624- 643 (36.59/15.93) PPHHTPPPVSSMAGNT..KNHP
644- 665 (27.42/ 9.88) MLMNLLKDNPAQDFSTLyGSSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 179.35| 42| 100| 838| 879| 6
---------------------------------------------------------------------------
838- 879 (79.55/49.62) PADLIADAAGSP..SSDSPTNHF....FPDGVDFNPDLLNSQSQ....SGFG
884- 905 (23.12/ 7.76) ......D....E..SSQSGDNDD....F.KG..FASQALNT...........
907- 942 (28.17/11.50) .........GVPmlGGDNGETKFkgnsQADTVDFS...IISVAS....KALG
943- 977 (48.51/26.59) PADLMEHHSG.....SQSP...L....LATG.....DLGKEKTQkrvkEGNG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.03| 17| 20| 541| 558| 7
---------------------------------------------------------------------------
541- 558 (30.58/17.54) PPASSPGYGMTTGNNpMS
563- 579 (34.45/15.45) PTNTFPGGPITTLFN.MS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 92.78| 27| 70| 1460| 1494| 10
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1460- 1486 (45.33/33.83) PQNLDSESESGSSIAEKSYQNSPSSDD
1517- 1543 (47.45/18.79) DRDKDRDKKKSHSIKPENWSKSPISSD
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|
