<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18752
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFMGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGSIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRSSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL |
Length | 2210 |
Position | Middle |
Organism | Macaca nemestrina (Pig-tailed macaque) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Macaca.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.385 |
Instability index | 57.95 |
Isoelectric point | 5.67 |
Molecular weight | 242697.02 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18752
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 74.48| 21| 28| 1595| 1620| 1
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1578- 1594 ( 5.71/ 6.29) ...SASGSSVppvSSS....ASA...P....
1600- 1620 (39.61/15.97) STTSSSGFSG...SVG....GQN...PSTGG
1622- 1649 (29.17/ 8.41) STDRTQGSIG...CGGdtdpGQSssqPSQDG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.93| 26| 28| 2068| 2095| 2
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2068- 2095 (37.05/29.10) GsHFQhSRSQGERL...LSREAPEELKQQPL
2098- 2126 (44.88/25.32) G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 97.76| 27| 28| 1010| 1036| 3
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1022- 1049 (34.69/12.92) VTLNSAAPASNSGAG...........vlpsP........ATPRFSVP
1050- 1091 (38.32/15.09) TPRTPRTPRTPRGGGtasgqgsvkydstdqG.....SPASTPSTTRP
1533- 1573 (24.75/ 6.95) .PAAAQGQATPGNAG.....plapngsaapPagsafNPTSNSSTTNP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.82| 26| 27| 1858| 1884| 4
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1858- 1884 (42.51/28.32) IALPSRSRRSkVSAR..KIGLQKLWEWCI
1887- 1914 (43.32/24.51) VQMTSLPWRV.VIGRlgRLGHGELKDWSI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 410.01| 105| 112| 358| 462| 5
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321- 413 (122.18/56.63) .....................CGM.PLTPPTSP.EQailGESGGMQSAASHLVS...qdggmiTMHSPKRSGKIP..PKL.HNHMVHRVWKE.CILNRTQSKRSQMS..TP.TLEEEPASNPATWD
414- 526 (155.76/74.45) FVDPTQRVSCSCSRHKL.LKRCAVGPNRPPTMS.QP...GFSAGPSSSSSLPPP...asskhkTTERQEKGDKLQkrPLI.PFHHRPSVAEElCMEQDAPGQKLGLAgiDS.SLE...VSSSRKYD
529- 574 (43.10/14.66) MAVPSRNTSKQMNLNPMdSPHSPISP.LPPTLSpQP......RG.QETESLDPP........................................................................
619- 708 (88.96/39.00) .....................CGIRP.SNPESS.EKwwhSYRLPPSDDAEFRPPelqgercdaKMEVNSESTALQ..RLLaQPNKRFKIWQD....KQPQMQPLHFL..DPlPLSQQPGDS.....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.45| 19| 23| 949| 971| 6
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950- 969 (32.17/23.94) FAPLKMLPSHC.LLPLKiPDA
972- 991 (34.28/10.46) FRPSWAIPPKIeQLPMP.PAA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.96| 19| 23| 818| 837| 7
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831- 852 (22.43/15.14) PSKIPTV..gtEDRPLgKDGRAAV
1379- 1401 (28.53/14.48) PLPIPTLlvgyDKDFL.TISPFSL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.63| 16| 23| 1700| 1722| 8
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1699- 1716 (26.60/27.57) WLLSLMRC.YteMLDNLPE
1722- 1738 (26.03/ 8.41) FILQIVPCqY..MLQTMKD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.79| 13| 23| 1952| 1972| 9
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1952- 1964 (24.21/30.94) AMEPQGSFVVMPD
1977- 1989 (22.58/ 6.16) ALNMQSSQLNTPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.95| 25| 25| 60| 84| 10
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60- 84 (48.05/36.58) FIRCLQANLLCVWRRDVKPDCKELW
86- 110 (47.90/36.44) FWWGDEPNLVGVIHHELQVVEEGLW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 239.99| 74| 1266| 156| 235| 11
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156- 235 (115.18/87.87) PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
1425- 1501 (124.81/74.33) PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.29| 17| 17| 1234| 1250| 12
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1234- 1250 (30.27/15.38) TQPFASLSFLDYISSNN
1253- 1269 (33.02/17.41) TLPCVSWSYDRVQADNN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.13| 20| 28| 1132| 1158| 13
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1132- 1151 (40.30/33.67) CICACNMNIK.GADVGLYIPD
1162- 1182 (33.83/13.23) CGFSAIMNRKlGYNSGLFLED
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