<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18745
| Description |
Mediator of RNA polymerase II transcription subunit 1 |
| Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYINVRYVLCGIKVAHHGENPVVCVVDISLESWHLKGLVNLYNLPGDKLNMYLALQSLEQDLSKMAIMYWVDLILHGKCLAISTPRGGGFFFMCPIWPLFRNVTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGTAFPLISLVFDRTIFALYDLPYLETAYCRTLMFYLNLRSHSAAIEILTLFSSLSCRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLMTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYASQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
| Length | 1490 |
| Position | Middle |
| Organism | Macaca nemestrina (Pig-tailed macaque) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Macaca.
|
| Aromaticity | 0.05 |
| Grand average of hydropathy | -0.642 |
| Instability index | 53.95 |
| Isoelectric point | 9.10 |
| Molecular weight | 158809.80 |
| Publications | |
Function
| Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
|
| GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleolus GO:0005730 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
| GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl
estrogen receptor binding GO:0030331 IEA:Ensembl
LBD domain binding GO:0050693 IEA:Ensembl
nuclear receptor coactivator activity GO:0030374 IEA:Ensembl
peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl
promoter-specific chromatin binding GO:1990841 IEA:Ensembl
protein-containing complex binding GO:0044877 IEA:Ensembl
retinoic acid receptor binding GO:0042974 IEA:Ensembl
thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription corepressor activity GO:0003714 IEA:Ensembl
vitamin D receptor binding GO:0042809 IEA:Ensembl
|
| GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl
angiogenesis GO:0001525 IEA:Ensembl
animal organ regeneration GO:0031100 IEA:Ensembl
brain development GO:0007420 IEA:Ensembl
cell morphogenesis GO:0000902 IEA:Ensembl
cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl
cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl
cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl
embryonic heart tube development GO:0035050 IEA:Ensembl
embryonic hemopoiesis GO:0035162 IEA:Ensembl
embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl
embryonic placenta development GO:0001892 IEA:Ensembl
enucleate erythrocyte development GO:0048822 IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl
fat cell differentiation GO:0045444 IEA:Ensembl
intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl
keratinocyte differentiation GO:0030216 IEA:Ensembl
lactation GO:0007595 IEA:Ensembl
lens development in camera-type eye GO:0002088 IEA:Ensembl
liver development GO:0001889 IEA:Ensembl
mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl
mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl
megakaryocyte development GO:0035855 IEA:Ensembl
monocyte differentiation GO:0030224 IEA:Ensembl
mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl
negative regulation of apoptotic process GO:0043066 IEA:Ensembl
negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl
negative regulation of neuron differentiation GO:0045665 IEA:Ensembl
negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl
positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl
positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl
positive regulation of gene expression GO:0010628 IEA:Ensembl
positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl
positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
protein import into nucleus GO:0006606 IEA:Ensembl
regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl
retinal pigment epithelium development GO:0003406 IEA:Ensembl
thyroid hormone generation GO:0006590 IEA:Ensembl
thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl
ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl
|
Interaction
Repeat regions
| Repeats |
>MDP18745
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
8| 396.07| 50| 50| 970| 1019| 2
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950- 1003 (74.69/24.79) SPGSSGRSQ....TP.......P....GVAT..ppipKITIQ....IPK...GTVMVGKPSS.HSQ................YT....................SSGSVSSSGSK
1004- 1053 (46.19/12.23) SHHSHSSSS....SS.......S....SAST......S...................GK.....MKssksegssssklsssmYA....................SQGSSGSSQSK
1055- 1103 (43.42/11.00) SSQSGGKPG....SSpitkhglS....SGSS....stKMK.......PQ........GKPSSlMNP................SL....................SKPNISPS...
1104- 1140 (39.97/ 9.49) ..HSRPPGG....SD.......K....LAS............pmkpVP....GT....PPSS.KAK........................................SPISSGSGG
1141- 1188 (48.71/13.34) SHMSGTSSSsgmkSS.......SglgsSGSL.....sQKT.......P...........PSS.NSC................TA....................SSSSFSSSGSS
1189- 1244 (51.66/14.64) MSSSQNQHG....SS.......K....GKSPsrnkkpSLTAV....IDKlkhGVVTSG.PGG.EDP................L......................DGQMGVSTNS
1245- 1280 (49.71/13.78) SSHPMSSKH....NM.......S....GG.........................EFQGKREK.SDK................DK....................S..KVSTSGSS
1281- 1349 (41.72/10.26) VDSSKKTSE....SK.......N....VGST...gvaKIIIS....KHD...G....GSPSI.KAK................VTlqkpgessgeglrpqmasskNYGSPLISGST
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
7| 320.15| 50| 52| 604| 653| 3
---------------------------------------------------------------------------
493- 539 (47.33/19.01) R.HESvghGEDF................SK......V...........................SQN.....PILTslLQITGNGGSTI.......GSSPT.....PPHH............tPP.....P
558- 608 (43.22/16.66) K.DNP...AQDF................STLYGSSPL..........................ERQNsssgsPRME..ICSGSNKTKK.............................kkssrlPP...EKP
609- 663 (80.15/37.82) K.HQT...EDDF................QRELFSMDV..........................DSQN.....PIFD..VNMTADTLDTP.......HITPA.....PSQC...........stPPttyPQP
664- 699 (42.21/16.08) V.PHP...QPSI................QRMVRLSSS..........................DSIG.....P..D..V...................TDI.....LSDI.............AE...EAS
700- 778 (38.08/13.71) KlPST...SDDCpaigtplrdssssghsQSTLFDSDV......................fqtnNNEN.....PYTD.pADLIADAAGSPssdsptnHFFHD.....GVDF.............NP...DLL
779- 864 (29.39/ 8.73) N.SQS...QSGF................GEEYFDESSqsgdnddfkgfasqalntlgvpmlggDNGE.....TKFK..ANNQADTVDFS.......IISVAgkalgPADL.....mehhsgsqGP......
865- 921 (39.78/14.69) ..LMT...TGDL................GKEKTQKRV..........................KEGN.....GTSN..S.....TLAGP.......GLDSK.....PGKRsrtpsndgkskdkPP...KRK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.52| 12| 15| 1404| 1415| 4
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1404- 1415 (19.60/12.67) EKHKKHKKEKKK
1422- 1433 (19.91/12.99) DRDRDKDRDKKK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 99.07| 27| 30| 246| 272| 6
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246- 272 (50.08/27.90) IPLFETQPTYAPLYELITQFELSKD...PD
274- 303 (48.99/27.15) IPLNHNMRFYAALPGQQHCYFLNKDaplPD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.34| 13| 15| 355| 367| 7
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355- 367 (22.13/14.03) FPLISLVFDRTIF
372- 384 (22.21/14.11) LPYLETAYCRTLM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 60.38| 11| 64| 1322| 1332| 8
---------------------------------------------------------------------------
930- 938 (18.56/ 6.23) PSHSSSN..RP
1322- 1332 (22.51/ 9.59) PGESSGEGLRP
1389- 1397 (19.31/ 6.86) P..SSDDGIRP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.03| 17| 20| 449| 466| 9
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449- 466 (30.58/20.08) PPASSPGYGMTTGNNpMS
471- 487 (34.45/17.67) PTNTFPGGPITTLFN.MS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.00| 21| 31| 190| 211| 13
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190- 211 (37.69/20.86) FF..FMCPIwPLFRNVTPSFSSIT
222- 244 (36.32/15.35) FFlkFPQPI.PVSRAFVQKLQSCT
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|
