<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18742

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSGERNFPFLINDTATLYTSPRISFVLQSKFVFVGHLGRSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKTSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSTMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESANSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDVMYSTYAPPLFRLQTRLGEHLEKLDRNNVLVGYCLSHDQRWILKYIYDTLYSYNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2135
PositionMiddle
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.08
Grand average of hydropathy-0.389
Instability index52.73
Isoelectric point5.51
Molecular weight235029.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18742
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     754.96|     216|     421|    1288|    1595|       1
---------------------------------------------------------------------------
  945- 1061 (98.28/26.23)	.......................................................................................DGSNMDQeygPAYTPQTHT.SFGMPPSSappSNSGAGILPSPSTPRFPTPRTPR..TprtprgAGGPA.....SAqgSVKYENSDLYSPASTPSTCRPLNS.VEPATVPSIPEAH.SLYVNLILSE..S...........................................
 1364- 1595 (319.19/296.80)	NGAKSFfrDLTAIYESCrLGQHRPVSRLLTDGIMRVGSTASNKLSeklvaEWFSQAADGNNEAFSKlKLyAQVCRYdLGPYLASLPlDSSLLSQ...PNLVAPTSQ.SLITPPQM...TNTGNANTPSATLASAASSTMTM..T......SGVAI.....ST..SVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFG.SMNSNAAGSM..STQANTVQSgqLGGQQTSTlQTAGiSGESSS..LPTQPHPDVSE
 1794- 2018 (337.49/164.91)	SSARKF..GLQKLWEWC.LGLVQMSSLPWRVVIGRLGRIGHGELK.....DWSCLLSRRNLQSLSK.RL.KDMCRM.CGISAADSP...SILS....ACLVAMEPQgSFVIMPDS...VSTGSVFGRSTTLNMQTSQLNTPqdT......SCTHIlvfptSA..SVQVASATYTTENLDLAFNPN.NDGADGMGIFDLLDTGdDLDPDIINILpaSPTGSPVHS..PGSHYPHG.GDVG.KGQSTDrlLSTEPHEEVPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     526.81|     166|     424|     226|     457|       2
---------------------------------------------------------------------------
    6-  192 (274.93/145.89)	VPNGASLEDCHCNLFCLadltGIKWKKYVWQGPT.SAPILFPVT..EE....DPilSSFSRCLK.ADVLGVWRRDQRPGRrelwifwWGEDP.NFADLIHHDLSGERNFPFLIND......TATLYTSPRISFVLQSKFVfvghlGRSEHLSCSFTFFLHGDS.NVCTSVE...INQHQPVYllsEEHITLAQQ..SNSPFQVILCPF
  271-  457 (251.88/248.48)	IPTPSPVGSTHCSSSCL....GVHQVPASTRDPAmSSVTLTPPTspEEvqtvDP..QSAQKWVKfSSVSDGFNSDSTSHH.......GGKIPrKLANHVVDRVWQECNMNRAQNKrkysasSGGLCEEVTAAKVASWDFV.....EATQRTNCSCLRHKNLKSrNAGQQGQapsLGQQQQIL...PKHKTNEKQekSEKPQKRPLTPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.10|      63|      68|     773|     838|       3
---------------------------------------------------------------------------
  773-  838 (104.09/59.50)	DELTPGSKKSANGSDDKTSCK.ESKTGNLDPLSCiSTADLHKMYptPPSLEQHIMG...FSPMNMNNKEY
  842-  908 (102.00/49.88)	DTTPGGTVLEGNSSSIGAQFKiEVDEGFCSPKPS.EIKDFSYVY..KPENCQILVGcsmFAPLKTLPSQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      24|    1309|    1330|      10
---------------------------------------------------------------------------
 1309- 1330 (42.16/24.62)	P..EPLPIPTFLLGYDYDYLVLSP
 1334- 1357 (36.97/20.61)	PywERLMLEPYGSQRDIAYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.46|      38|    1047|     610|     649|      11
---------------------------------------------------------------------------
  610-  649 (63.39/60.52)	LPPQLPS...............DKFKDDPVGPfgQESVTSVTELMVQCKKPLKIS
 1658- 1710 (60.07/48.04)	LPPHIKStvsvqiipcqyllqpVKHEDREIYP..QHLKSLAFSAFTQCRRPLPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.92|      13|      28|    1077|    1089|      15
---------------------------------------------------------------------------
 1077- 1089 (27.02/16.16)	CVCN....MNIK.GADVG
 1103- 1120 (17.89/ 8.15)	CTCGfsaiMNRKfGNSSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18742 with Med13 domain of Kingdom Metazoa
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