<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18741

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSGERNFPFLINDTATLYTSPRISFVLQSKFVFVGHLGRSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKTSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSTMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESANSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDTECIRLNSTILYLAPVKDKQTELGEHLEKNNVLVGYCLSHDQRWILKYIYDTLYSYNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2138
PositionMiddle
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.08
Grand average of hydropathy-0.388
Instability index52.77
Isoelectric point5.47
Molecular weight235237.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18741
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1034.23|     282|     422|    1288|    1595|       1
---------------------------------------------------------------------------
  868- 1061 (170.33/75.69)	GF.CSPK.......PSEIKDFSyvykPENCQI...LVGcsmfaplktLPSQY..LPPI...KLP..............................................................................................................................eeciyrqswtvgklellssgstmpfikegDGSNMDQeygPAYTPQTHT.SFGMPPSSappSNSGAGILPSPSTPRFPTPRTPR..TprtprgAGGPA.....SAqgSVKYENSDLYSPASTPSTCRPLNS.VEPATVPSIPEAH.SLYVNLILSE..S..............................
 1288- 1584 (450.39/218.94)	PL.TWQQFHKMAGRGSYGTDES....PEPLPIPTFLLG.........YDYDYLVLSPF...ALPYWERL....MLEPY...GSQRDI.AYV..VLCPENEALLNGAKSFFRDLTAIYESCrLGQHRPVSRLLTDGIMRVGSTASNKLSeklvaEWFSQAADGNNEAFSK.LKlyaQVCRYdLGPYLASLP............................lDSSLLSQ...PNLVAPTSQ.SLITPPQM...TNTGNANTPSATLASAASSTMTM..T......SGVAI.....ST..SVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFG.SMNSNAAGSM..STQANTVQSgqLGGQQTSTlQTAGiSGESSS
 1706- 2008 (413.51/174.01)	PLpTSTNVKTLTGFGPGLAMET....ALRSP.DTECIR.........LNSTILYLAPVkdkQTELGEHLeknnVLVGYclsHDQRWIlKYIydTLYSYNRARRKKSSARKFGLQKLWEWC.LGLVQMSSLPWRVVIGRLGRIGHGELK.....DWSCLLSRRNLQSLSKrLK...DMCRM.CGISAADSP...............................SILS....ACLVAMEPQgSFVIMPDS...VSTGSVFGRSTTLNMQTSQLNTPqdT......SCTHIlvfptSA..SVQVASATYTTENLDLAFNPN.NDGADGMGIFDLLDTGdDLDPDIINILpaSPTGSPVHS..PGSHYPHG.GDVG.KGQSTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     779.63|     206|     423|     226|     433|       2
---------------------------------------------------------------------------
  226-  433 (342.10/181.71)	CLK..EMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFV......LVP.QSD.IPTPSPVGSTHCSSSclGVHQVPA.STRDPAMSSVTLTP...PTSPEEVQTVDPQSAQKWVKFSSVSDGFNS.DS..TSHHGGKIP..RKLANHVVDRVWQEC..NMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHK....NLKSRNAGQ..QGQAPSLGQQQQI
  497-  629 (161.46/78.54)	.........................................................................VAKTP..QMHGTEMANSPQPP...PLSPHPCDVVD.EGVTK.TPSTPQSQHFYQ.MP..TP..DPLVP..SKPMEDRIDSLSQSFppQYQEAVEPTVYVGTAVNLEED..EANIA.WKYYKVPKKKDVEFLPPQlpsdKFKDDPVGP..FGQ..........
  642-  863 (276.07/140.90)	CKKplKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVegdeefLFPdKKDrQNSEREAGKKHKVED..GTSSVTVlSHEEDAMS..LFSPsikQDAPRPASHARPPST.SLIYDSDLAVSFTDlDNlfNSDEDELTPgsKKSANGSDDKT..SC..KESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYG....SMDTTPGGTvlEGNSSSIGAQFKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.60|      11|     425|    1585|    1595|       3
---------------------------------------------------------------------------
 1585- 1595 (21.83/12.18)	LPTQPHPDVSE
 2011- 2021 (20.78/11.15)	LSTEPHEEVPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.68|      26|      28|    1079|    1106|       4
---------------------------------------------------------------------------
 1081- 1106 (49.59/31.41)	MNIK.GADVGVYIPDPTQEAQYRCTCG
 1111- 1137 (42.09/19.17)	MNRKfGNSSGLFLEDELDIIGRNTDCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.06|      37|     799|    1245|    1282|       7
---------------------------------------------------------------------------
 1245- 1282 (59.65/45.09)	WSKRNDVSMQCSQdILRMLLSLQ.PVLQ.DAIQKKRTVRP
 2046- 2084 (61.41/41.29)	WSACPQAQYQCPL.FLKASLHLHvPSVQsDELLHSKHSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.58|      42|     262|     173|     214|       8
---------------------------------------------------------------------------
  173-  214 (72.32/42.33)	EHITLAQQ..SNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLI
  436-  479 (68.26/39.52)	KHKTNEKQekSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18741 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
2) GSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHE
3) GSTMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
4) NLFNSDEDELTPGSKKSANGSDDKTSCKES
5) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
6) VAPTSQSLITPPQMTNTGNANTPSATLASAA
407
1985
935
766
1512
1461
568
2017
1020
795
1610
1491










Molecular Recognition Features






MoRF SequenceStartStop




NANANA