<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18738

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSGPRLRGRKEKRQAWGRIKLGSLNCIFYFHLTDLLWPWQVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVATGLEPQAQGQLPRLGMQPVNWVGDSME
Length2140
PositionKinase
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.501
Instability index56.84
Isoelectric point6.76
Molecular weight238550.87
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18738
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     166.04|      16|      16|    2025|    2040|       1
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 2025- 2040 (37.67/15.73)	QQQQQQQQQ.....QQQQQQQ
 2055- 2070 (33.80/13.36)	QQQQQQILR.....QQQQQQQ
 2071- 2086 (37.67/15.73)	QQQQQQQQQ.....QQQQQQQ
 2087- 2102 (34.42/13.74)	QQQQHQQQQ.....QQQAAPP
 2103- 2123 (22.48/ 6.44)	QPQPQSQPQvatglEPQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     104.19|      18|      18|    1705|    1722|       2
---------------------------------------------------------------------------
  682-  698 (22.42/ 7.82)	PDFSLFSP....TMPCEGKGS
 1705- 1722 (31.45/14.64)	PRAYYLEP...LPLPPEDEEP
 1723- 1743 (25.39/10.06)	PAPTLLEPekkAPEPPKTDKP
 1766- 1782 (24.93/ 9.72)	P.AAKTED...YGMGPGRSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.04|      18|      20|    1920|    1938|       3
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 1920- 1938 (30.44/21.53)	PYVSHVGLQQhTGPAGTMV
 1988- 2005 (29.85/15.32)	QRFSHQTLQQ.TPMISTMT
 2006- 2021 (22.75/ 9.46)	P.MSAQGVQ..AGVRSTAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1027|    1039|       4
---------------------------------------------------------------------------
 1027- 1039 (25.11/19.63)	ENPAA.HTFTYTGL
 1045- 1058 (21.03/14.92)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.17|      83|     149|    1106|    1195|       5
---------------------------------------------------------------------------
 1106- 1195 (128.66/98.79)	GTCGFNDLLCNVDVSDLSFhDSLATFVAILIARQCLLLEdliRCaaIPSLLNAACSEQDSEPGARLTCRiLLHLFKTPQLNPCQSDGNKP
 1257- 1339 (147.51/90.60)	GSGGRRQGGRNISVETASL.DVYAKYVLRSICQQEWVGE...RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICYPHRLLDNEDGENP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      18|    1634|    1651|       6
---------------------------------------------------------------------------
 1634- 1651 (18.50/19.94)	NKIAGFDsIFkkEGLQVS
 1654- 1668 (30.32/18.08)	QKISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      18|     859|     875|       7
---------------------------------------------------------------------------
  863-  875 (24.86/22.80)	MSYHLPLVQHVQF
  880-  892 (22.52/ 7.78)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.51|      16|      18|     346|     363|       8
---------------------------------------------------------------------------
  346-  363 (26.01/18.96)	FSDLLM.CPQhrPLVFGLS
  366-  382 (26.49/12.47)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.33|      39|     125|    1817|    1855|       9
---------------------------------------------------------------------------
 1817- 1855 (72.57/43.70)	QPLPAGGPRVDP..YR...PV.....RLPMQKLPTRPTYPGVL.........PTTMTG
 1857- 1911 (44.45/23.17)	MGLEPSSYKTSV..YRqqqPAvpqgqRL.RQQLQAKIQSQGMLgqssvhqmtPSSSYG
 1945- 1983 (63.31/36.94)	QPYQSTHPSTNPtlVD...PT.....R.HLQQRPSGYVHQQA..........PTYGHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.34|      46|     150|    1343|    1393|      10
---------------------------------------------------------------------------
 1343- 1393 (64.88/52.21)	RIKriLQNLD..........QWTMRQSSL..ELQLMIKQTPNNEMnSLLENIAKATIEVfqQS
 1488- 1545 (70.46/40.06)	RIK..LGSLNcifyfhltdlLWPWQVGGMfdTVQRSTQQTTEWAM.LLLEIIISGTVDM..QS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     365.04|     102|     338|     160|     266|      11
---------------------------------------------------------------------------
  160-  266 (171.01/133.09)	IKMTCAYyaAISeTKVKKRHVDpfMEWTQIITKYLWE.QLQKMAEYYRPGPAGGGGCGSTIGP.LPHDVEV....AIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIR
  450-  497 (41.03/19.36)	.........................................................GFTIGR.VLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.IS
  504-  605 (153.00/102.09)	VSLLCEW..AVS.CKRSGRHRA..MVVAKLLEKRQAEiEAERCGESEAADEKGSIASGSLSAPsAPIFQDV....LLQFLD..TQAPMLTDPRSESERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      22|     613|      13|      35|      14
---------------------------------------------------------------------------
   13-   35 (40.01/20.65)	PLKRPRlGPPDVYPQDPKQKEDE
  629-  650 (45.34/20.29)	PGPRPP.SPFDDPADDPEHKEAE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18738 with Med12 domain of Kingdom Metazoa
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