<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18737

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMGDPFSLFPPEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQVGIVVLFIFSFTLSDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKGLGSGPRLRGRKEKSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVATGLEPQAQGQLPRLGMQPVNWVGDSME
Length2155
PositionKinase
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.444
Instability index53.34
Isoelectric point6.50
Molecular weight239377.22
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18737
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.16|      16|      16|    2079|    2094|       1
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 2069- 2084 (25.63/ 9.03)	QGVQAGVRSTQQQQQQ
 2085- 2100 (32.66/13.51)	QQQQQQQQQQQQQQQQ
 2111- 2124 (21.88/ 6.64)	..QQQAAPPQPQPQSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     895.09|     221|     230|     372|     600|       2
---------------------------------------------------------------------------
  160-  368 (257.73/145.71)	.......................IKMTC.......AYY..AAIS.ETK..VKK.RHVDPFMGDPFSLFPPEWTQIITKYLWEQLQKMAEYYRP.GPA.....G..GGGC.....GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqvgivvlfifsftlsDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSSlPTTPAPQPPTSSTP...STP
  372-  600 (355.74/222.12)	LLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWS..FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL....................DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ
  603-  836 (281.62/161.62)	MLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAP...GPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV...................kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.50|      20|      21|    1979|    1999|       4
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 1923- 1937 (21.73/ 6.86)	.YKTSVYRQQQ....PA...VPQ
 1979- 1999 (38.48/23.06)	PYVSHVGLQQH..TGPAgTMVPP
 2000- 2020 (26.29/ 9.97)	SYSSQPYQSTHpsTNP..TLVDP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     876|     890|       5
---------------------------------------------------------------------------
  876-  890 (26.85/15.06)	LEQITSFALG.MSYHL
  892-  907 (23.14/12.07)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.76|      13|      15|    1477|    1491|       6
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 1477- 1491 (18.90/14.65)	GQHLgsSSRKERDRQ
 1497- 1509 (23.86/11.70)	GPRL..RGRKEKSQQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.61|      18|      21|    1791|    1811|       7
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 1791- 1811 (27.34/23.26)	KKAPEPPKTDKPGAappSTEE
 1814- 1831 (30.28/15.93)	KKSTKGKKRSQPAA...KTED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      14|      17|    1694|    1710|       8
---------------------------------------------------------------------------
 1694- 1710 (16.87/16.82)	KIAGFDsIFkkEGLQVS
 1714- 1727 (28.71/15.16)	KISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1591|    1604|       9
---------------------------------------------------------------------------
 1591- 1604 (24.50/16.22)	LLEIIISGTV..DMQS
 1615- 1630 (20.20/12.02)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.21|      21|      21|    1854|    1874|      10
---------------------------------------------------------------------------
 1836- 1847 (18.60/ 6.50)	..PG........RSGPYGVTVP
 1854- 1874 (39.52/23.36)	PNPGSITHLN.YRQGSIGLYTQ
 1877- 1896 (31.08/16.56)	PLPAGGPRVDpYR..PVRLPMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.94|      12|      21|    2026|    2037|      12
---------------------------------------------------------------------------
 2026- 2037 (24.39/12.20)	QRPSGYVHQQAP
 2047- 2058 (23.56/11.54)	QRFSHQTLQQTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      11|      21|    1098|    1108|      13
---------------------------------------------------------------------------
 1098- 1108 (21.19/12.09)	AILCAELTGYC
 1121- 1131 (22.77/13.59)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.56|      25|      26|    1183|    1207|      14
---------------------------------------------------------------------------
 1183- 1207 (44.13/25.86)	CSEQDSEPGARLTCRILLHLFKTPQ
 1211- 1235 (43.43/25.33)	CQSDGNKPTVGIRSSCDRHLLAASQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.99|      18|     231|    1390|    1455|      18
---------------------------------------------------------------------------
 1362- 1379 (33.10/66.70)	PQRQRIKRILQNLDQ...W....TM
 1431- 1455 (19.88/ 9.41)	PSSSKTKPVLSSLERsgvWlvapLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      22|      22|    1641|    1662|      24
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 1641- 1662 (34.88/18.62)	RAYMNLAKKLQKELGERQSDSL
 1666- 1687 (37.82/20.82)	RQLLPLPKQTRDVITCEPQGSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18737 with Med12 domain of Kingdom Metazoa
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