<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18731

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPRPLHTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length788
PositionTail
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.03
Grand average of hydropathy-0.704
Instability index88.65
Isoelectric point9.54
Molecular weight86858.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18731
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     242.77|      42|      43|     177|     218|       1
---------------------------------------------------------------------------
  177-  218 (79.33/16.83)	L.......QQQQQQQQQQFQ..AQQSAMQQQF.QA..VVQQQQQQLQQQQQQQQ
  220-  264 (53.66/ 8.37)	LiklhhqnQQQIQQQQQQLQrmAQLQ.LQQQ........QQQQQQQQQQQQQQA
  265-  298 (60.37/10.58)	L.......QAQP.......P..IQQPPMQQPQ.PP..PTQALPQQLQQMHHPQ.
  328-  368 (49.41/ 6.96)	L.......VSQAQALPGQML..YTQPPLK..FvRApmVV..QQPPVQPQVQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     510.09|     144|     154|     430|     582|       2
---------------------------------------------------------------------------
  302-  416 (60.85/ 7.97)	..................................................................PPPQPQQPPVA....QN......QPSQLP..PQ..SQTQP.........lvsqaqalpgqmlytqpplkfvrapmvvqqppvqpqvqqqtavQTA....QAAQMVAPGVQMITealaqggmHIRARFPPTTAVSAV..........PSSSIP
  430-  581 (242.72/62.41)	LP....MLSSPSPGQQVQTPqsmPPPPQPsPQPGQPGSQP.....NSNVSSgPAPSPS...SFLPSPSPQPSQSPVTArtPQNFSVPSPRPLHTPVNPS..SVMSPaGSSQAEEQ...........................................QYLDKLKQLSKYIEPLRRMIN........KIDKNEDRKKDLSKMKSL.LDILTDPSKRCP
  585-  734 (206.52/44.40)	LQkceiALEKLKNDMAVPTP...PPPPVP.PTKQQYLCQPlldavLANIRS.PVFNHSlyrTFVPAMTAIHG.PPITA..P..VVCTRKRRLEDDERQSipSVLQ..GEVARLDP...........................................KFLVNLDPSHCSNNGTVHLIC........KLD...D..KDLPSVPPLeLSVPADYPAQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.02|      16|      20|      87|     106|       3
---------------------------------------------------------------------------
   87-  102 (30.23/10.38)	SLTGGPAAGAAGIGMP
  109-  124 (29.79/ 9.77)	SLGGMGSLGAMGQPMS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18731 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) PLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPRPLHTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
70
345
258
148
538
337










Molecular Recognition Features






MoRF SequenceStartStop




1) HIRAR
396
400