<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18706

Description Mediator complex subunit 23
SequenceMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ
Length1290
PositionTail
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.10
Grand average of hydropathy0.005
Instability index44.32
Isoelectric point7.86
Molecular weight147361.87
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.22|      24|      89|     987|    1014|       1
---------------------------------------------------------------------------
  419-  446 (40.13/19.28)	ETIYGNGIMRIplpgTNCMASGSITPLP
  987- 1010 (47.09/37.43)	DTYYCRLIGRL....VDTMAGKSPGPFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.84|      14|      43|     247|     274|       2
---------------------------------------------------------------------------
  247-  270 (19.27/31.87)	GTSQLLWqhlssqliffVLFQFAS
  290-  303 (28.56/ 9.14)	GRDHLMW..........VLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.73|      28|      43|     523|     551|       3
---------------------------------------------------------------------------
  523-  551 (48.25/42.81)	LHTLLEMFSYRM......HHIQPHYrVQLLSHLHT
  563-  596 (42.48/31.41)	LHLCVESTALRLitalgsSEVQPQF.TRFLSDPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.41|      47|      49|     116|     164|       8
---------------------------------------------------------------------------
   64-  110 (51.23/25.63)	.IPNTVSSAVVQQLL.AARevIAYILERnaC.LLPAY...FAVTEIRKLYPEG.
  116-  164 (77.08/49.73)	LLGNLVSDFVDTFRP.TAR..INSICGR..CsLLPVVnNSGAICNSWKLDPATL
  168-  210 (66.10/35.01)	LKGLLPYD.KDLFEPqTAL..LRYVLEQ......PY..SRDMVCNMLGLNKQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     169.19|      41|     372|     846|     886|       9
---------------------------------------------------------------------------
  325-  350 (37.65/18.81)	....YPEKEYI..........PVPDINKPQSTHAFAMTCI...
  846-  886 (79.40/47.44)	YHKKYPEKLYFEG..LAEQVDPPVQIQSPYLPIYFGNVCLRFL
 1221- 1254 (52.14/28.75)	YHMKY....MFTGdsVKEQVEKIICNLKPALKLR.....LRFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.45|      46|     262|     893|     938|      10
---------------------------------------------------------------------------
  893-  938 (84.36/50.79)	IHRFLE..LLPVSKSLETLL..DHLGGLY..KFHDRPVTYLYN.TLHYYEMHL
 1149- 1201 (65.09/37.51)	IPKFLTevLLPIVKTEFQLLyvYHLVGPFlqRFQQERTRCMIEiGVAFYDMLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      30|     262|     462|     495|      11
---------------------------------------------------------------------------
  462-  495 (43.92/43.94)	IHSIATRVIKLAHAKSSValapALVETYSRLLVY
  725-  754 (52.03/39.66)	INQIGYRVLERIGARALV....AHVRTFADFLVY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18706 with Med23 domain of Kingdom Metazoa
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