<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18694

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFACLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1809
PositionKinase
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.415
Instability index53.75
Isoelectric point7.61
Molecular weight203690.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18694
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     159.21|      29|     150|     753|     781|       1
---------------------------------------------------------------------------
  753-  781 (50.37/25.92)	CL..ILNPDQTAQVFEG...L...CGVVKHV..V.NPSEC
  902-  931 (38.39/18.13)	CT..VLSSEWLG.VLKA...L...CCSSNHVwgF.NDVLC
  943-  969 (23.42/ 8.40)	SLatFIAILIARQCF.S...L...EDVVQHV..A.LP...
  970- 1001 (25.53/ 9.78)	SL..LAAACGDADAEPGarmT...CRLLLHL..FrAPQA.
 1002- 1022 (21.50/ 7.15)	CF..L..PQATGKPFPG...IrssCD..RH..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.49|      49|     150|    1605|    1656|       2
---------------------------------------------------------------------------
   27-   61 (27.65/ 8.16)	...................QDPKQKEDELTavnvkqgfnNQPAFTGDE....HGSARN
 1605- 1634 (35.10/12.36)	...................QEPERKSAELS.........DQGKTTTDEEKKTKGRKRK
 1638- 1656 (19.10/ 6.25)	SSRVDEYPQSNIYRVPPNY.......................................
 1660- 1704 (75.63/32.97)	SSQMMHHPQSTLWGYNLVGQ.PQQPGFFLQ.........NQSLTPGGSRLDPAGS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.50|      30|      66|    1095|    1137|       5
---------------------------------------------------------------------------
 1095- 1124 (56.89/49.61)	ETANL.REYARYVLRTICQ....QEWVG.....EHCLKEP
 1162- 1201 (39.60/13.89)	EGDNLqRQHIKRILQNLEQwtlrQSWLElqlmiKQCLKDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     347.05|     116|     732|     531|     705|       6
---------------------------------------------------------------------------
  531-  668 (168.35/142.23)	TSL.GRRMSVNCEKLvkrEKPRELIFPSNYDLLRHLQyathfpipldESSSHECNQRTI.LLYGVGKERDEARHQ.LKKITKDILKILNKksTTETGVGDEgQKARKNKQETFPtletvfTKLQLL.SYFDQHQVTSQISNN
 1283- 1402 (178.71/100.84)	TSVqGRVLKAAGEEL...EKGQHLGSSSKKERDRQKQ..........KSMSLLSQQPFLsLVLTCLKGQDEQREGlLTSLQNQVNQILSN..WREERYQDD.IKARQMMHEALQ......LRLNLVgGMFDTVQRSTQWTTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.34|      15|      18|    1224|    1241|       8
---------------------------------------------------------------------------
 1227- 1241 (25.73/20.87)	SADLNNSSNSGMSLF
 1248- 1262 (25.61/10.46)	SADTSSTRQNGIKTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.68|      14|      23|    1501|    1515|       9
---------------------------------------------------------------------------
 1501- 1515 (19.75/16.66)	GSLIDTKgNKIAGFD
 1522- 1535 (25.93/16.26)	GLQVSTK.QKVSPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.73|      11|      23|    1768|    1778|      11
---------------------------------------------------------------------------
 1768- 1778 (19.44/10.07)	RQGLQQTQQQQ
 1788- 1798 (19.29/ 9.93)	QKQLSSNQPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.86|      18|      23|    1405|    1422|      12
---------------------------------------------------------------------------
 1405- 1422 (29.93/18.93)	LLLLQIITSGTVDMHTNN
 1429- 1446 (28.93/18.06)	LDMLGVLINGTLASDLSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.28|      31|     307|     406|     436|      20
---------------------------------------------------------------------------
  406-  436 (51.96/29.63)	ESEVLDEKESISSSSLAGS...SLPV.FQNVLLRF
  716-  750 (41.32/22.16)	ELSVVEAELLLKSSSLAGSyttGLCVcIVAVLRRY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18694 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
2) RSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
3) TQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
1683
1581
1774
1734
1665
1809










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGLLSYEQRPLKRPRLGPPDVY
2) RSYYLQPLPLP
1
1581
25
1591