<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18693

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFACLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQQPQPQQPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2148
PositionKinase
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index59.09
Isoelectric point7.97
Molecular weight240392.20
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18693
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     697.11|     185|     203|    1715|    1917|       1
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 1588- 1708 (158.57/72.88)	................................SPGGSE.ENKRAYMN.....LVKKLKKELGDKR....S........ESID...................KV..................RQLLPL...PKQTC...DV.....IT.............CEPMGSLIDTKGNkiagFDSIDKKQGL............Q......................VSTKQKVSPWDLFEGQKNPA....PLSWAWfgtvrvDRRVIKYEEQHH
 1709- 1911 (309.93/187.75)	LLLYHTHPMPKPRsyylqpLplppeeeeeePtSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSS........SRVDeYPQSN...........IYRVPPNY.........SPIS.SQMMHH...PQSTLWGYNL.....VGQPQQPGFFLQNQSLTPGGSRLDPAGS....FVPTNTKQALSNMLQRRSGAMMQP..P..............SLHAITSQQQLIQMKLLQQQQQQR....LLRQAQ......TRPFQQGQPGDQ
 1912- 2135 (228.62/114.06)	AALFAAQARPSPQ......L..........P.....QYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSvvlspsynSRA..YPAAHsnpvlmerlrqIQQQPSGYvqqqaspylQPLTgSQRLNHqalQQSPLVGGGIdavltSAHPNLPSVPLPQDPMRP...R.QP.........QVRQQQRLLQMQQPQQPQQPQPqqPpqpqqssqpqsqtlGLQAMQPQQPLFPRQGLQQTQQQQqtaaLVRQLQ.......KQLSSNQP...
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     444.37|     138|     150|    1053|    1202|       2
---------------------------------------------------------------------------
 1053- 1148 (122.08/107.63)	......................................................................LKALCCSSN..HVWG.F..N.DVLCTVDVS..DLSFHDSLATFIAILIARQCFSLEDVVQH.VALPS.....LLAAACGDAD..AEPG.ARMTCRLLLHLFrapqaCFlPQAT
 1149- 1297 (174.36/156.17)	GKPFPgiRSSCDRHLLAAAHNSIEVGavFAVLKAIM..MLGDAkiGNNSVSSLKN..D.........dftMRGLRCDGNadDIWT.AsqN.PKSCGKSISieTANLRE.YARYVLRTICQQ....EWVGEHcLKEPE.....RL...CTDKEliLDPVlSNMQAQKLLQLI.....CY.PHGI
 1303- 1443 (147.94/111.49)	GDNLQ..RQHIKRILQNLEQWTLRQS..WLELQLMIkqCLKDP..GSGSVAEMNNllDniakatievfqqSADLNNSSN..SGMSlF..NpNSIGSADTS..S.TRQNGIKTFLSSSERRGVWLVAPLIAR...LPTsvqgrVLKAA.GE.E..LEKG.QHL.....................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.23|      18|     203|     710|     731|       5
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  710-  731 (29.71/25.84)	HFPIPLDESSSHECnqrtILLY
  914-  931 (35.52/20.21)	HVVNPSECSSPERC....ILAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.07|      23|     251|     554|     584|       8
---------------------------------------------------------------------------
  554-  576 (40.08/15.95)	ESISSSSLAGS...S..LPV.FQNVLLRF
  811-  834 (30.78/ 9.27)	EQITSFA.SGT...SyhLPL.AHHIQLIF
  864-  890 (26.21/ 7.86)	LLLKSSSLAGSyttG..LCVcIVAVLRRY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.47|      12|     251|     408|     419|       9
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  408-  419 (25.34/14.90)	PMPG.....GNTAFNQQ
  660-  676 (18.13/ 8.42)	PMPGescenANTSLGRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      11|     251|     744|     790|      13
---------------------------------------------------------------------------
  732-  742 (20.75/31.11)	GVGKERDEARH
  764-  774 (20.30/21.57)	GVGDEGQKARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.54|      24|      27|    1471|    1494|      15
---------------------------------------------------------------------------
 1471- 1494 (38.62/21.97)	VLTCL...KGQDE..QREGLLTSLQNQVN
 1496- 1524 (30.92/16.04)	ILSNWreeRYQDDikARQMMHEALQLRLN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18693 with Med12 domain of Kingdom Metazoa
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