<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18692

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKELPLAKSGVPQVPILSKKEDVFACLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVWGREMRAMPSSFRQCKYATVKK
Length2098
PositionKinase
OrganismMacaca nemestrina (Pig-tailed macaque)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.396
Instability index56.62
Isoelectric point8.09
Molecular weight234759.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18692
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     132.69|      19|      19|    1898|    1916|       1
---------------------------------------------------------------------------
 1898- 1916 (36.94/18.33)	QQQQQQRLL....RQA.QTRP..FQQ
 1937- 1950 (20.81/ 6.85)	...PQYPGL....QQA.QTMP....Q
 1998- 2016 (31.46/14.43)	QIQQQPSGY....VQQ.QASP..YLQ
 2017- 2036 (22.27/ 7.90)	PLTGSQRLN....HQAlQQSP..LVG
 2066- 2090 (21.20/ 7.13)	QVRQQQRLLqvwgREM.RAMPssFRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     875|     891|       2
---------------------------------------------------------------------------
  875-  891 (22.97/17.52)	LLLKSSSLAGSYtTGLC
  905-  920 (29.21/17.65)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     281.02|     112|     203|    1287|    1433|       3
---------------------------------------------------------------------------
 1287- 1420 (162.58/153.98)	DPVLSNMQAQKLLQLIC.YP..HGIKECTEGDNLQRQHIKRILQN.....LEQW.............................................................................................tlRQSWLELQLMIKQCLKDPGSGSVAEMNNLLdNIAKATIEVfqqsadlnnssnsgMSlFNPnsIGSadTSSTRQNGIKTFLSSSERR
 1458- 1511 (31.51/16.36)	SKKERDRQKQKSMSLLSqQPflSLVLTCLKGQDEQREGLLTSLQNqvnqiLSNW.....................................................................................................................................................................................
 1607- 1672 (86.94/49.51)	......................................................reeryqddikarqmmhealqlrlnlvggmfdtvqrstqwttdwallllqiitsgtvdmhtnnelfttvldmlgvlingtlasdlsnaspggseenKRAYMNLVKKLKKELGDKRSESIDKVRQLL.PLPKQTCDV..............IT.CEP..MGS..LIDTKGNKIAGFDSIDKKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.13|      29|     251|     565|     595|       4
---------------------------------------------------------------------------
  565-  595 (41.08/35.40)	ESISSSSlAGSS..LPVFQNVLLRFlDTQAPSL
  822-  852 (47.05/30.54)	EQITSFA.SGTSyhLPLAHHIQLIF.DLMEPAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.57|      31|     252|     690|     723|       6
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  690-  723 (48.43/40.08)	VNCEKLvkREKPRELiFPSNYDLLRHLQYATHFP
  948-  978 (56.14/35.33)	VSCSHL..RSKFGDL.FSSACSKVKQTIYNNVMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.03|      24|      27|    1008|    1032|       7
---------------------------------------------------------------------------
 1008- 1032 (40.04/32.67)	GKIlSD..NAANRYSFVCNTLMNVCMG
 1037- 1062 (38.99/26.42)	GRI.NDiaNFSSELTACCTVLSSEWLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.84|     123|     202|      21|     165|       8
---------------------------------------------------------------------------
   21-  165 (176.87/152.48)	P.PDV.YPQ.DPKQKEDELTAVNvkqGFNNQPAFTGDehGSarnIVINPS.....KIGAYfssilAEKLKLNTFQDTgkkkpqVNAKDNY..WLvTARSQSAIHSWFSD.LAGNKPLSILAKKELPL.AKSGVPQVPILSKKE....DVFAClAKYSvPMV
  192-  266 (73.05/36.82)	PdPNLeWTQiSTRYLREQLAKIS...DFYHMASSTGD..GP...VPVPPEveqamKQWEY.....NEKLAFHMFQEG......MLEKHEYltWI...................................................................
  307-  372 (69.93/30.86)	.........................................................................................Y..F..CARRLSLLLSDSPNlLAAHSPHMMIGPNNSSIgAPSPGPPGPGMSPVQlafsDFLSC.AQHG.PLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.26|      13|     202|    1063|    1083|      11
---------------------------------------------------------------------------
 1063- 1080 (19.29/27.87)	VLKALCCSSnhvwgFNDV
 1101- 1113 (22.97/ 6.64)	ILIARQCFS.....LEDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.08|      13|     202|     725|     742|      12
---------------------------------------------------------------------------
  725-  738 (19.59/23.04)	PLDEsSSHECNQRT
  747-  759 (21.50/ 6.90)	ERDE.ARHQLKKIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.90|      20|      23|     500|     521|      15
---------------------------------------------------------------------------
  500-  521 (30.60/26.61)	WANQNKDNQEvaPNDEAVVTLL
  524-  543 (35.30/23.79)	WAVSCKRSGK..HRAMAVAKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.61|      23|      29|    1126|    1149|      21
---------------------------------------------------------------------------
 1119- 1133 (19.30/ 6.25)	.........LPSLLAA..ACGDADAE
 1134- 1159 (35.88/22.22)	PGARMTCRlLLHLFRApqACFLPQAT
 1164- 1177 (20.43/ 7.31)	PGIRSSCD..RHLLAA..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.11|      10|      19|    1222|    1232|      22
---------------------------------------------------------------------------
 1222- 1232 (16.69/13.77)	CdGNADDIWTA
 1239- 1248 (18.42/ 9.56)	C.GKSISIETA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18692 with Med12 domain of Kingdom Metazoa
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