<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18628

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGGTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKTSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGAAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPAQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESANSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.08
Grand average of hydropathy-0.395
Instability index53.21
Isoelectric point5.38
Molecular weight239276.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18628
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.69|      23|      27|     974|     999|       1
---------------------------------------------------------------------------
  980- 1005 (36.35/18.26)	THTSFGMP..PSSaPPSNSGAG................ilP..SPS
 1006- 1049 (25.39/12.68)	T.PRFPTPrtPRT.PRTPRGAGgpasaqgsvkyensdlysPasTPS
 1483- 1503 (37.95/15.90)	TSQSLITP..PQM...TNTGNA..................N..TPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.43|      26|      31|    1519|    1549|       2
---------------------------------------------------------------------------
 1524- 1545 (28.74/18.66)	..........TSV...ATANSTLTTASTSSSSSSN
 1546- 1577 (38.13/19.31)	LNSGvssnklPSF...PPFGSMNSNAAGSMSTQAN
 1579- 1603 (26.56/10.93)	VQSG.........qlgGQQTSTLQTAGISGESSS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.57|      19|      26|     524|     544|       3
---------------------------------------------------------------------------
  463-  483 (28.43/ 8.70)	EKSEKPQKRPLTPfhHRVSVS
  526-  544 (39.13/23.80)	EMANSPQPPPLSP..HPCDVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.25|      20|      26|    1328|    1349|       5
---------------------------------------------------------------------------
 1328- 1349 (35.82/22.05)	P..EPLPIPTFllGYDYD..YLVLSP
 1353- 1376 (30.43/13.27)	PywERLMLEPY..GSQRDiaYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     527.06|     186|     424|     245|     452|       6
---------------------------------------------------------------------------
  233-  307 (13.47/30.87)	............................................................................................................................................................IGEWKQFypiscclKEMSEEKQedmdweddslAAVEVLV...AGVRMIYPAcfvlVPQsDIPTPS....PVGSTHCSSSCLG
  309-  462 (221.94/132.76)	HQVPASTRDPAMSS..VTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTS..HHG.............GKIPRKLANHVVDRvWQECNMNrAQNKR..KYSASSGGLCEEvtAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQI.....lpKHKTNEKQ............................................................
  618-  777 (211.92/115.84)	YKVP.KKKD.......VEFLPPQLP....................SDKFKDDPVG..PFGqesvtsvtelmvqCKKPLKISDELVQQ.........YQIKN..QYLSAIASDAEQ..EPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVED.GT.............................SSVTVLSheeDAMSLFSPS....IKQ.DAPRPAsharPPSTSLIYDSDLA
  778-  866 (79.74/34.43)	..VSFTDLDNLFNSdeDELT.PGSKKSANGSDDKTSCKESKTGNL.DPLSCISTAdlHKM.............YPTPPSLEQHIMG..FSPMNMN...NKEygSMDTTPGG...............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.06|      13|     424|    1381|    1399|      13
---------------------------------------------------------------------------
 1381- 1393 (21.58/22.58)	LLNGAKSFFRDLT
 1400- 1412 (22.48/ 6.53)	RLGQHRPVSRLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.77|      63|     816|    1186|    1301|      16
---------------------------------------------------------------------------
 1186- 1301 (82.35/120.47)	DDlillLQDQCTNLF..SPFGAADQDP...FPKSGvisnwvrveerdccndcylalehgrqfmdnmsggkvdealvkssclhpWSKRNDVSMQCSQdILRMLLSLQ.PVLQ.DAIQKKRTVRP
 2005- 2120 (80.41/39.17)	DD....LDPDIINILpaSPTGSPVHSPgshYPHGG..dvgkgqstdrllstepheevpnilqqplalgyfvstakagplpdwfWSACPQAQYQCPL.FLKASLHLHvPSVQsDELLHSKHSHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18628 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
2) ATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPAQPHPDVSESTMDRDKVGIPTDGD
3) CLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGGTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPP
4) GSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHE
5) NLFNSDEDELTPGSKKSANGSDDKTSCKES
6) VAPTSQSLITPPQMTNTGNANTPSATLASAA
956
1527
426
2021
785
1480
1039
1629
588
2053
814
1510










Molecular Recognition Features






MoRF SequenceStartStop




NANANA