<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18625

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQVGIVVLFIFSFTLSDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVFLRAFVLFPRVNDIAILAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVATGLEPQAQGELPRLGMQPVNWVGDSME
Length2174
PositionKinase
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.07
Grand average of hydropathy-0.466
Instability index56.75
Isoelectric point6.53
Molecular weight242497.59
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18625
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     145.42|      15|      15|    2059|    2073|       1
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 2059- 2071 (25.56/ 6.94)	....QQQQQQQQQQQQQ
 2072- 2088 (26.56/ 7.45)	QQqqQQQQQQQQQYHIR
 2089- 2103 (30.33/ 9.39)	QQ..QQQQILRQQQQQQ
 2104- 2119 (30.94/ 9.70)	QQ.qQQQQQQQQQQQQQ
 2120- 2134 (32.02/10.26)	QQ..QQQHQQQQQQQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.56|      39|     353|     321|     359|       2
---------------------------------------------------------------------------
  321-  359 (70.38/30.65)	LQL.DGVSSHSSHVISAQST....SSLPTTPAPQPPTSSTP.ST.P
 1761- 1781 (30.67/ 9.37)	L........................LEPEKKAPEPPKTDKPgAA.P
 1946- 1990 (58.51/24.29)	LQTsQGYTPYVSHVGLQQHTgpagTMVPPSYSSQPYQSTHP.STnP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.12|      18|     353|    1677|    1705|       3
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 1656- 1674 (28.41/ 8.46)	CEPQGSLIDTKgNKIAGFD
 1677- 1694 (32.71/35.54)	FKKEGLQVSTK.QKISPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.19|      72|     233|    1147|    1223|       5
---------------------------------------------------------------------------
 1147- 1223 (110.47/76.51)	LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRIVDG
 1383- 1459 (102.72/55.96)	LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      16|     867|     881|       6
---------------------------------------------------------------------------
  867-  881 (26.85/16.95)	LEQITSFALG.MSYHL
  883-  898 (23.14/13.55)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.85|      20|     231|    1907|    1929|       7
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 1793- 1811 (33.92/13.67)	KGKK.RSQPAAKTEDYGMGP
 1912- 1929 (26.67/16.33)	QGQRLRQQLQAKIQSQGM..
 2150- 2165 (23.26/ 8.35)	....LEPQAQGELPRLGMQP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      16|    1333|    1347|       9
---------------------------------------------------------------------------
 1333- 1347 (21.57/16.81)	HRLLDNEDgENPQRQ
 1350- 1363 (26.45/15.28)	KRILQNLD.QWTMRQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.69|     100|     231|     527|     635|      10
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  527-  635 (145.60/117.50)	SCKRSGRHRAMVVAKLLEKR.QAEIEAERCGES..EAADEKGSIASGSLsAPSAPIfQDVLLQFL...DTQAPMLTDPRSESERVEFFNlvlLFCELIRHDvfSHNMytCTLISR
  759-  864 (157.09/98.02)	SCSHECNQRLVVLFGVGKQRdDARHAIKKITKDilKVLNRKGTAETDQL.APIVPL.NPGDLTFLggeDGQKRRRNRPEAFPTAEDIFA...KFQHLSHYD..QHQV..TAQVSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.74|       9|      16|    1041|    1050|      11
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 1041- 1050 (13.93/13.86)	ENPaAHTFTY
 1059- 1067 (17.81/11.54)	ENP.ANRYSF
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.94|      12|      18|    2001|    2018|      12
---------------------------------------------------------------------------
 2001- 2012 (24.39/26.48)	QRPSGYVHQQAP
 2022- 2033 (23.56/ 6.82)	QRFSHQTLQQTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.44|      10|      18|     366|     377|      14
---------------------------------------------------------------------------
  366-  377 (16.13/17.51)	CPQhrPLVFGLS
  387-  396 (22.31/14.33)	CPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.69|      23|      25|    1838|    1862|      15
---------------------------------------------------------------------------
 1813- 1831 (26.88/ 6.24)	RSGPYGVTVPPDLLHHPNP....
 1840- 1862 (42.73/21.35)	RQGSIGLYTQNQPLPAGGPRVDP
 1866- 1884 (27.07/ 8.84)	....VRLPMQKLPTRPTYPGVLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      15|     198|    1096|    1110|      18
---------------------------------------------------------------------------
 1096- 1110 (30.98/17.61)	EWLG..VLKALCCSSNN
 1295- 1311 (26.87/14.34)	EWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1566|    1579|      20
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 1566- 1579 (24.50/15.58)	LLEIIISGTV..DMQS
 1590- 1605 (20.20/11.53)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.36|      22|     627|      13|      35|      26
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   13-   35 (40.01/19.89)	PLKRPRlGPPDVYPQDPKQKEDE
  643-  664 (45.34/19.55)	PGPRPP.SPFDDPADDPEHKEAE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18625 with Med12 domain of Kingdom Metazoa
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