<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18619

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVACLQSQLLGETESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNEASQSGPYHLSYRKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLMTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1575
PositionMiddle
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.04
Grand average of hydropathy-0.677
Instability index54.31
Isoelectric point8.81
Molecular weight167546.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18619
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     173.06|      40|      41|    1068|    1107|       1
---------------------------------------------------------------------------
 1028- 1076 (38.41/ 6.81)	TSTG.....GSK.SPGSSGRSQTP.......PGVATPpiPKitiqipkgtvmvGKPSS.HSQY
 1077- 1126 (54.39/13.12)	TSSGSVSSSGSK.SHHSHSSSSSS.......SSASTS..GK.mkssksegsssSKLSS..SMY
 1127- 1179 (36.90/ 6.22)	SSQGSSGSSQSKnSSQSGGKPGSSpitkhglSSGSSS..TK........mkpqGKPSSlMNPS
 1262- 1309 (43.36/ 8.77)	ASSSSFSSSGSS.MSSSQNQHGSS.......KGKSPS..RN...kkpsltaviDK.LK.HGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.77|      41|      41|     763|     803|       2
---------------------------------------------------------------------------
  609-  645 (38.74/12.03)	...STIGS..SPT......PPHHTPPPV....SSmagntKNHPM.........LMNLLKDN
  763-  803 (61.71/24.60)	SSSDSIGP..DVTDILSDIAEEASKLPS....TS.....DDCPA.........IGTPLRDS
  820-  865 (37.12/11.15)	QTNNNENPytDPADLIAD....AAGSPS....S.......DSPTnhffhdgvdFNPDLLNS
  972- 1003 (29.20/ 6.81)	SNSTLAGP..G....LDSKPGKRSRTPSndgkSK.....DKPP..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     231.66|      49|      50|    1395|    1444|       4
---------------------------------------------------------------------------
 1217- 1244 (47.50/11.31)	SPISSG.SGG...SHMSG.........................................................TSSSSG......MKSSSGLG
 1329- 1379 (35.88/ 6.88)	....SS.SHPmssKHNMSGGEF..................qgkrekSD...............KDKSKVS......TSGSSVdsSKKTSESKNVG
 1380- 1426 (61.73/19.38)	STGVAKiIIS...KHDGGSP...........................................SIKAKVTLQKPgESSGEGL..RPQMASSKNYG
 1427- 1482 (51.35/12.78)	SPLISG.STP...KHERGSPSH......................skSPaytpqnldsesesgsSIAEKSYQNSP..SSDDGI..RP.........
 1483- 1543 (35.22/ 6.63)	..LPEY.STE...KHKK....HkkekkkvkdkdrdrdrdkdrdkkkSH...............SIKPESWSKSP.ISSDQSL....SMTSN....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     142.40|      27|      43|     279|     305|       5
---------------------------------------------------------------------------
  279-  305 (50.39/36.29)	PSF.SSITSANSVDLPACFFL.KFPQPIP
  321-  349 (42.05/28.69)	PLFeTQPTYAPLYELITQFELsKDPDPIP
  357-  376 (24.94/13.10)	........YAALPGQQHCYFLnKDA.PLP
  384-  398 (25.02/13.17)	TLV.SKITFQH.............PGRVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.13|      29|      35|     872|     902|       6
---------------------------------------------------------------------------
  872-  900 (42.73/26.80)	.......GEEYFDESSQSGDNDDFkGFASQA.LNTLG
  902-  935 (39.97/21.96)	PmlggdnGETKFKANNQA.DTVDF.SIISVA.GKALG
  936-  954 (28.43/ 9.60)	P......AD..LME.HHSG.........SQGpLMTTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.24|      48|     149|      57|     113|       7
---------------------------------------------------------------------------
   57-  113 (65.37/66.74)	SGGH....QHLVSCLETLQKalKVTSlPAMTDRlESIARQNGLGSHLSASGtecyiTSDMF
  208-  259 (78.87/49.87)	SGGHlmnlKYYVSPSDLLDD..KTAS.PIILHE.NNVSRSLGMNASVTIEG.....TSAMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.26|      17|      20|     534|     551|       8
---------------------------------------------------------------------------
  534-  551 (29.44/20.21)	PPASSPGYGMTTGNNpMS
  556-  572 (31.83/16.25)	PTNTFPGGPITTLFN.MS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.16|      34|      35|     135|     169|      12
---------------------------------------------------------------------------
  135-  169 (56.28/42.61)	ENPV..SCPELVQQLREKNFDEFSKHLKGLVNlYNLP
  171-  206 (55.88/37.42)	DNEAsqSGPYHLSYRKATNAGPLDKILHGSVG.YLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.00|      12|     117|     586|     597|      13
---------------------------------------------------------------------------
  586-  597 (23.63/13.64)	EDFS.KV.SQNPIL
  704-  717 (15.37/ 6.10)	ELFSmDVdSQNPIF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18619 with Med1 domain of Kingdom Metazoa
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