<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18614

Description Mediator complex subunit 14
SequenceMVDFSGQIVAFTTPGGGGGRESGKGKGGATADVPADDSDSALTLVSAAVAAAAAAAASPGYRLMPRNPCLFPKIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSVHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1443
PositionTail
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.07
Grand average of hydropathy-0.183
Instability index50.50
Isoelectric point8.99
Molecular weight159162.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18614
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.65|      65|      66|    1002|    1066|       1
---------------------------------------------------------------------------
  941- 1002 (84.95/29.88)	...GFYPA.PGL.KTFLNM....FVDSN.QD.A..RRRSVNEDDNPPSPIGGDMMD..SLISQLQ.PPPQQQPFPkqP
 1003- 1069 (117.22/43.65)	GTSGAYPL.TSP.PTSYHS....TVNQS.PSMM..HTQSPGNLHAASSPSGALRAP..SPASFVPTPPPSSHGISigP
 1070- 1122 (70.72/23.80)	GASFASPHgTLD.PSSPYT....MV..S.PSGR..AGNWPGS.PQVSGPSPAARLPgmSPAN......PS........
 1123- 1181 (46.76/13.57)	.......L.HSPvPDASHSpragTSSQTmPTNMppPRKLPQRSWAASIPTILTHSA..LNILLLPSPTP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     235.22|      76|     184|       3|      85|       3
---------------------------------------------------------------------------
    3-   85 (109.39/90.86)	DFSGQIVAFTTpGGGGGRESGKGKGGATADVPADDSDSALTLVSAAVAAAAAAAASpGYRLMPRNPCLF.PKIVQfaSRtrqLF
  196-  272 (125.83/79.19)	DLPPQLANLTV.ANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGD.GRALVHSMQISFiHQLVQ..SR...LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     280.85|      87|     159|     283|     374|       4
---------------------------------------------------------------------------
  283-  374 (143.63/107.46)	NCLHSFCLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTIKIDENDVSKplqiFHDPPLPA.SDSKL
  434-  527 (137.21/89.33)	PCGNSECLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTISSETLQLSN....YSTHPIGNlSKNKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.75|      11|      24|     756|     767|       5
---------------------------------------------------------------------------
  756-  767 (16.58/15.27)	LNDWNSIaRLYE
  783-  793 (19.17/11.96)	LNIFSEV.RVYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.08|      59|     507|     811|     910|       6
---------------------------------------------------------------------------
  679-  741 (94.13/50.83)	CKG.ISEETQKALDRS.....LLDCTFRLQGRNNRtwVAELvfANCPLNGTSTREQG........P..SRHVYLTYENL
  836-  910 (81.96/81.12)	CHNtILHQLQEMFNKTpnvvqLLQVLFDTQAPLNA..INKL..PTVPMLGLTQRTNTayqcfsilPqsSTHIRLAFRNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|    1352|    1375|       8
---------------------------------------------------------------------------
 1351- 1374 (39.65/23.52)	KMLFFL..QLTQKTSVPPQEPVSIIV
 1375- 1400 (34.41/19.24)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1236|    1250|      10
---------------------------------------------------------------------------
 1236- 1250 (21.47/16.98)	LKCRVALSP.KTNqTL
 1274- 1288 (22.14/11.97)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.53|      33|     807|     386|     420|      11
---------------------------------------------------------------------------
  386-  420 (46.03/36.27)	IEKLLiDSVHARAH.QKLQElKAILRGFNANENSSI
 1196- 1229 (52.50/32.19)	LERFL.GSVIMRRHlQRIIQ.QETLQLINSNEPGVI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18614 with Med14 domain of Kingdom Metazoa
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