<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18610

Description Mediator of RNA polymerase II transcription subunit 13
SequenceGGAGASMPSLSAPPSKNLHSFKLTHELCFRKMFQKFLFIWMSFLLFCFFLFSFFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFMGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGSIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2163
PositionMiddle
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.07
Grand average of hydropathy-0.376
Instability index58.54
Isoelectric point5.81
Molecular weight237614.60
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18610
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     503.66|     107|     112|     773|     879|       1
---------------------------------------------------------------------------
  479-  565 (111.40/49.42)	...............DKQMAV.PSRN.TSKQMNLNPMD.SP.........HSPISPLP.PTLSPQPRGQETesldPPS.....VPVNPAL.....Y.GN..GLEL.QQLSTLD....DRTVL......VGQRLPLMAEV
  567-  686 (126.01/56.98)	ETALYCGIRPSNPesSEKWWHSYRLP.PSD....DAEF.RPpelQGErcDAKMEVNSE.STA..LQRLLAQ....PNKrfkiwQDKQPQMQP.LHF.LDplPLSQ.QPGDSLG...EVNDPYtfedgdIKYIFTANKKC
  773-  866 (144.80/66.71)	...............DELGAVSPALR.PSKIPTVGTED.RP...LGK..DGRAAVPYP.PTVADLQRMFPT....PPS.....LEQHPAFSPVMNY.KD..GISS.ETVTALG...MMESPM......VSMVSTQLTEF
  867-  972 (121.44/54.61)	KMEVEDGLGSPKP..EEIKDFSYVHKvPSFQPFMGSSMfAP...LKM.lPSHCLLPLKiPDACLFRPSWAI....PPK.....IEQLP.MPPAATFiRD..GYNNvPSVGSLAdpdYLNTPQ......MN.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     417.73|     153|    1266|     109|     370|       2
---------------------------------------------------------------------------
  174-  370 (220.67/205.91)	TGQAYKMSDPATRKLieEWQYFYPMVLKKKEESKEEDElgyddDFPVAVeVIVGgvrmvYPSAFVLISQNDIPVPQS..VASAGGH.................................................................................................................................................................itvgqqglgsvkdpsncgmpltppTSPEQAILGESGGmQSAASHLVSQDGgmiTMHSPKRSGKIPPKLHNHMVHRVWKECIlnrTQSKRSQMST.PTLEEEPASNPATWDF.VDP
 1296- 1368 (93.94/15.98)	TGRTWENIQHVQGPL..TWQQFHKMAGRGTYGSEESPE.....PLPIPT.LLVG.....YDKDFLTISPFSLPFWERllLDPYGGH....................................................................................................................................................................................................................................................................................
 1554- 1637 (103.11/20.85)	......................................................................................rdvayivvcpeneallegaktffrdlsavyemcrlgqhkpickvlrdgimrvgktvaqkltdelvsewfnqpwsgeendnhsrlklyaqvcrhhlapylatlqldssllippkyqtppaaaqgqatpgnagplapngsaappagsafnptsnssttnpaasssasgssvppvsssasapgisqisTTSSSGFSGSVGG.QNPSTGGISTDR...TQGSIGCGGDTDPGQSSSQPSQDGQESV...TERERIGIPTePDSADSHAHPPAVVIYmVDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1266|     109|     142|       3
---------------------------------------------------------------------------
  109-  142 (52.23/37.52)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1378- 1409 (59.04/33.95)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2021|    2048|       4
---------------------------------------------------------------------------
 2021- 2048 (37.05/24.72)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2051- 2079 (44.88/21.52)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     254.74|      66|     480|     994|    1061|       5
---------------------------------------------------------------------------
  391-  429 (54.95/18.16)	.........................PNRPPTMSQPGFSAGPSSSSS...LPPPAS.S...KHKT.TERQEKG
  973- 1009 (26.87/ 9.42)	............................TPVT...LNSAAPASNSGagvLP....sPAtpRFSVPTPRTPRT
 1010- 1061 (83.23/31.05)	PRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQP...IPEAHS.................
 1492- 1547 (89.69/34.45)	QATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAAS.SSASGSS...VPPVSS.SA....SAP.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.19|      26|      28|    1811|    1837|       6
---------------------------------------------------------------------------
 1811- 1837 (42.59/39.74)	IALPSRSRRSkVSAR..KIGLQKLWEWCI
 1840- 1867 (42.60/33.63)	VQMTSLPWRV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.04|      23|      26|    1693|    1718|       7
---------------------------------------------------------------------------
 1696- 1718 (44.77/33.93)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1720- 1747 (30.27/12.65)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      24|    1650|    1669|       8
---------------------------------------------------------------------------
 1650- 1669 (31.05/21.56)	NFWLLSLMRCyTEMLDNLPE
 1673- 1691 (34.81/19.13)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      11|      24|    1983|    1994|      10
---------------------------------------------------------------------------
 1983- 1994 (17.73/12.87)	PFPDDmDNDIGI
 2010- 2020 (21.55/10.30)	PSPGS.PSGIGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18610 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVP
2) ECILNRTQSKRSQMSTPTLEEEPASNPATWDFV
3) EKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQ
4) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
6) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
7) KRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
8) PPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGSIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADS
9) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
757
336
583
1993
689
258
385
1479
957
806
368
623
2041
755
326
542
1623
1054










Molecular Recognition Features






MoRF SequenceStartStop




NANANA