<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18608

Description Transducin beta like 1 X-linked
SequenceMTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQAAAAAASAAATAAATTSASVSQQHPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNILLASASFDSTVRLWNIERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Length573
PositionTail
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.07
Grand average of hydropathy-0.328
Instability index42.22
Isoelectric point6.15
Molecular weight62187.70
Publications









Function






Annotated function


GO - Cellular Component
histone deacetylase complex	GO:0000118	IEA:Ensembl
mitotic spindle	GO:0072686	IEA:Ensembl
transcription repressor complex	GO:0017053	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:Ensembl
histone binding	GO:0042393	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
transcription factor binding	GO:0008134	IEA:Ensembl
transcription regulatory region sequence-specific DNA binding	GO:0000976	IEA:Ensembl

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
positive regulation of canonical Wnt signaling pathway	GO:0090263	IEA:Ensembl
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl
proteolysis	GO:0006508	IEA:Ensembl
sensory perception of sound	GO:0007605	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     376.50|      40|      40|     381|     420|       1
---------------------------------------------------------------------------
  224-  253 (34.14/14.46)	..............LRGHESE...........VFICAWNPVS.........dlLASGSGDSTAR
  272-  309 (44.61/20.90)	HCirEGGHDVP..S....NKD...........VTSLDWNTNG.........tlLATGSYDGFAR
  310-  339 (31.64/12.93)	I...WTEDGNLASTLGQHKGP...........IFALKWNRKG..........nY..........
  340-  391 (45.24/21.28)	IL..SAGVDKTTIIWDAHTGEakqqfpfhsapALDVDWQNNT..........tFASCSTDMCIH
  392-  433 (62.90/32.14)	VC..RLGCDRPVKTFQGHTNE...........VNAIKWDPSG.........mlLASCSDDMTLK
  434-  484 (58.61/29.50)	IW..SMKQEVCIHDLQAHNKE...........IYTIKWSPTGpatsnpnsnilLASASFDSTVR
  488-  526 (54.87/27.20)	IE..RGVC...IHTLTKHQEP...........VYSVAFSPDG.........kyLASGSFDKCVH
  527-  563 (44.49/20.82)	IW..NTQSGNLVHSYRG.TGG...........IFEVCWNARG........dkvGASASD.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18608 with Med16 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AATTSASVSQQHPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKA
171
221










Molecular Recognition Features






MoRF SequenceStartStop




NANANA