<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18605

Description Uncharacterized protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSNSGMSLFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLS
Length1791
PositionKinase
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index53.40
Isoelectric point7.61
Molecular weight201800.16
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.41|      51|      66|    1667|    1720|       1
---------------------------------------------------------------------------
 1667- 1720 (82.54/54.52)	QSTLWGYNLVGQPQQPGFFLQNQSlTPggSRLDPAGSFVPTNTKQ...ALSNMLQRR
 1736- 1789 (82.87/45.13)	QQQLIQMKLLQQQQQQRLLRQAQT.RP..FQQFPRQGLQQTQQQQqtaALVRQLQKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.50|      30|      66|    1095|    1137|       3
---------------------------------------------------------------------------
 1095- 1124 (56.89/54.88)	ETANL.REYARYVLRTICQ....QEWVG.....EHCLKEP
 1162- 1201 (39.60/15.53)	EGDNLqRQHIKRILQNLEQwtlrQSWLElqlmiKQCLKDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     203.52|      45|     154|     735|     781|       6
---------------------------------------------------------------------------
  735-  779 (80.94/41.57)	YTTGL..CVCIVAV..LRRYHSCL..ILNPDQTAQVFEGL...CGVVKHVVNPS
  894-  923 (43.03/17.36)	FSSEL..TAC............CT..VLSSEWLG.VLKAL...CCSSNHV....
  925-  970 (42.99/19.89)	...GFndVLCTVDVsdL.SFHDSLatFIAILIARQCF.SL...EDVVQHVALPS
  989- 1022 (36.56/15.78)	.......CRLLLHL..FRAPQACF..L..PQATGKPFPGIrssCD..RH.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.58|      38|     154|    1052|    1089|       8
---------------------------------------------------------------------------
 1052- 1089 (70.82/50.85)	GNNSVSSLKN..DDF...TMRGLR..CDGNADDIWTASQNPKSCG
 1202- 1246 (51.76/34.90)	GSGSVAEMNNllDNIakaTIEVFQqsADLNNSNSGMSLFNPNSIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.21|      24|    1001|     551|     578|      16
---------------------------------------------------------------------------
  551-  578 (35.42/36.43)	RELIfpsNYDLLRH.LQYATHfPIPLDES
 1557- 1581 (43.79/28.05)	RRVI...KYEEQHHlLLYHTH.PMPKPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|      29|     592|     603|      17
---------------------------------------------------------------------------
  592-  603 (22.36/15.14)	GVGKERDEARHQ
  624-  635 (21.93/14.69)	GVGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.05|      24|      27|    1330|    1353|      20
---------------------------------------------------------------------------
 1330- 1353 (38.59/22.48)	VLTCL...KGQDE..QREGLLTSLQNQVN
 1355- 1383 (31.46/16.91)	ILSNWreeRYQDDikARQMMHEALQLRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.29|      43|     307|     479|     525|      21
---------------------------------------------------------------------------
  479-  525 (70.59/55.07)	CTLISRGDLSVTAStRPRSPAGenaDEHYSKDHDVKMEIFSP.MPGES
  787-  830 (75.70/46.95)	CILAYLYDLYVSCS.HLRSKFG...DLFSSACSKVKQTIYNNvMPANS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18605 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHA
2) RSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
1682
1580
1732
1664










Molecular Recognition Features






MoRF SequenceStartStop




1) MAAFGLLSYEQRPLKRPRLGPPDVY
2) RSYYLQPLPLP
1
1580
25
1590