<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18588

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVGESPGRLREALVTRQLKRATAVPSPRPHSFPRGLALAFHDGSVHIVHRLSLQTMAVFYSSATPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGHGPDACVTSRAAEEAPAFVQLGPWPTYRPPRTPRSLDHPHPEDHLTARGPRGPWGDPARAPASVFLPLLPRALNLDKLQLGRAGPINALCAHNLGAAPNKRPGPAHNLGVVPGSLCPLGLSLNQYLWGT
Length939
PositionTail
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.06
Grand average of hydropathy-0.038
Instability index50.29
Isoelectric point8.48
Molecular weight103278.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18588
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     152.82|      31|      32|     714|     744|       1
---------------------------------------------------------------------------
  714-  741 (44.30/20.97)	..........ASDG.....................................L.VSRLQPK.QPL.RLQFGRAPT...LPGS
  742-  776 (29.11/11.25)	AATlqldglaRAPG...........................................QPKiDHLrRLHLGACPT...EECK
  777-  840 (27.36/10.13)	ACT...........rcgcvtmlkspnrttavkqweqrwiknclcghgpdacV.TSRAAEE.APA.FVQLGPWPT...YRPP
  851-  877 (27.71/10.36)	..........PEDH.....................................L.TAR.GPR.GPW.G.DPARAPAsvfLP..
  886-  914 (24.33/ 8.19)	............DK.....................................LqLGRAGPI.NALcAHNLGAAPN..kRPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.99|      19|      37|     425|     445|       3
---------------------------------------------------------------------------
  425-  445 (30.68/26.40)	GIDNQGKLsvLRLSPSMGHPL
  465-  483 (38.31/26.11)	GYDWWDIL..LHVQPSMVQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.24|      27|     134|      22|      48|       4
---------------------------------------------------------------------------
   22-   48 (53.17/24.89)	EKWSKSTHCPSVPLACAWSCRNLIAFT
  157-  183 (49.06/22.48)	EKFSRVKFSPSLTLFGGKPMEGWIAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.47|      30|      38|     606|     643|       9
---------------------------------------------------------------------------
  584-  613 (33.05/23.76)	...FVLDMNTL..QALQQLLQWVGdfvLYLLASLP
  622-  654 (46.13/23.66)	GHSFLRDGTSL..GMLRELMVVIRiwgLLKPSCLP
  658-  681 (25.29/10.40)	ATSDTQDSMSLlfRLLTKLWICCR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.22|      20|      39|     336|     355|      12
---------------------------------------------------------------------------
  336-  355 (34.18/20.69)	REALVTRQLKRATAVPSP..RP
  376-  397 (31.04/18.10)	RLSLQTMAVFYSSATPRPvdEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18588 with Med16 domain of Kingdom Metazoa
Unable to open file!