<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18559

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length678
PositionTail
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.04
Grand average of hydropathy-0.814
Instability index92.37
Isoelectric point9.38
Molecular weight76052.30
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     338.31|      80|      81|      69|     148|       2
---------------------------------------------------------------------------
   69-  139 (115.92/22.40)	............IHNK...............KSQASVSAQLQLQQVA.LQQQQQQQQFQQQQ......QAALQQQQQQQQQQFQA....QQSAMQ..QQFQAV...VQQQQQQL
  140-  221 (124.89/24.86)	QQQQQQQQHlikLHHQ...............NQQQIQQQQQQLQRMAqLQLQQQQQQ..QQQ......Q....QQQQQQQQALQAqppiQQPPMQ..QPQPPP...TQALPQQL
  222-  320 (97.50/17.35)	QQMHHPQHH.......qpppqpqqppvaqnqPSQ..LPPQSQTQPLV.SQAQALPGQMLYTQpplkfvRAPMVVQQPPVQPQVQ.....QQTAVQtaQAAQMVapgVQVSQSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     237.08|      44|      45|     325|     369|       3
---------------------------------------------------------------------------
  325-  368 (88.34/31.43)	SPSPGQQVQTPQSMPPPPQPSPQPGQPGSQP.....NSNVSSGP..AP.SPS
  373-  406 (44.93/11.12)	SPSP.QPSQSPVTARTP........QNFSVP.........SPGPlnTPvNPS
  486-  527 (51.54/15.76)	..KNDMAVPTP...PPPPVP.PTKQQYLCQPlldavLANIRS.P..VF.NHS
  587-  624 (52.26/14.19)	HCSNNGTVHLICKLDDKDLPSVPPLE.LSVP.........ADYP..AQ.SP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.30|      16|      36|     423|     439|       4
---------------------------------------------------------------------------
  423-  439 (23.61/17.16)	LDKLKQLSKYIePLRRM
  460-  475 (28.69/16.40)	LDILTDPSKRC.PLKTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18559 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
188
428










Molecular Recognition Features






MoRF SequenceStartStop




1) LKFVRA
276
281