<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18558

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length789
PositionTail
OrganismMandrillus leucophaeus (Drill) (Papio leucophaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Mandrillus.
Aromaticity0.03
Grand average of hydropathy-0.703
Instability index88.63
Isoelectric point9.49
Molecular weight86864.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18558
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     364.12|      43|      43|     177|     219|       1
---------------------------------------------------------------------------
  150-  181 (52.42/ 7.88)	...QTQLQ.LQ......QVALQQ......QQQQQQFQQQQQ..AA...L.......QQQQ
  182-  231 (74.41/15.15)	QQQQQQFQ.AQ......QSAMQQQFQAVVQQQQQQLQQQQQQQQH...LiklhhqnQQQI
  232-  270 (63.69/11.61)	QQQQQQLQrMA......QLQLQQQ.....QQQQQQQQQQQQQQQA...L.......QAQP
  271-  309 (57.31/ 9.50)	.......P.IQ......QPPMQQPQPPPTQALPQQLQQMHHPQHHqppP.......QPQQ
  335-  375 (49.94/ 7.06)	ALPGQMLY.TQpplkfvRAPM......VV..QQPPVQPQVQQQTA...V.......QTAQ
  437-  474 (66.35/12.49)	PSPGQQVQ.TP......QS.M....PPPPQPSPQPGQPGSQPNSN...V.......SSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.16|      17|      21|      86|     106|       2
---------------------------------------------------------------------------
   86-  102 (32.30/10.28)	QSLTGGPAAGAAGIGMP
  108-  124 (31.86/ 9.95)	QSLGGMGSLGAMGQPMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.05|      35|      93|     398|     436|       3
---------------------------------------------------------------------------
  401-  436 (61.85/34.06)	RFPPTTAVSAVPSSSIPLGrQPMAQVSQSSL..PMLSS
  475-  494 (27.19/ 6.05)	......APS..PSSFLP...SPSPQPSQSPV.......
  497-  526 (50.01/17.23)	RTPQNF...SVPSPG.PLN.TP...VNPSSVmsPAGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      29|      34|     534|     564|       5
---------------------------------------------------------------------------
  534-  564 (40.72/39.12)	LDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
  571-  600 (46.90/33.91)	LDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.24|      17|     299|     303|     329|       6
---------------------------------------------------------------------------
  310-  329 (30.33/11.28)	PPVAQNQPSQLPPQSqtqPL
  720-  736 (32.91/ 6.80)	PPLELSVPADYPAQS...PL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18558 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) PLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
70
346
259
148
539
338










Molecular Recognition Features






MoRF SequenceStartStop




1) HIRAR
397
401