<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18551

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGRKKPQVNAKDNYWLVTPRSQSVIHSWFSELAGNKPLSVLAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQSTDPNLEWTQISTRYLREQLAKISDFYHMASSSGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWPNQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGGGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSAELNNNSSNSGMSFFNPNSIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQKSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVQQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHHKPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1810
PositionKinase
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.07
Grand average of hydropathy-0.429
Instability index53.51
Isoelectric point7.49
Molecular weight203980.30
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18551
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.80|      23|     151|     753|     781|       1
---------------------------------------------------------------------------
  753-  776 (35.49/33.33)	CLILNpDQTAQVFEGLCGVVKHVV
  799-  821 (37.31/16.49)	CSHLR.SKFGDLFSSACSKVKQTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.32|      51|     151|    1606|    1657|       2
---------------------------------------------------------------------------
 1606- 1657 (77.15/43.22)	QEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEyPQ.............SNI..YRVPPNY
 1680- 1732 (58.61/28.11)	Q.PQQPGFFLQNQSLTP........GGSRLDPAGSFV...PTntkqalsnmlqrrSGA..MMQPPSL
 1758- 1810 (77.56/39.51)	QAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQ.PQ.............QGVtpYGHPSHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.74|      19|      29|     971|     989|       3
---------------------------------------------------------------------------
  971-  989 (36.45/23.61)	LLAA..ACGDADAE....PGARMTC
  995- 1019 (27.29/15.67)	LFRApqACFLPQATgkpfPGIRSSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.11|      10|      14|    1071|    1081|       4
---------------------------------------------------------------------------
 1071- 1081 (16.69/15.44)	CdGNADDIWTA
 1088- 1097 (18.42/10.72)	C.GKSISIETA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      90.30|      32|     151|    1295|    1335|       6
---------------------------------------------------------------------------
 1295- 1313 (21.88/ 6.76)	...................G..............................................................................................................................................EELEKGQHLGSSSKKERD
 1322- 1334 ( 9.54/14.11)	LLSQQPFLSLVLT.......................................................................................................................................................................
 1477- 1494 (22.21/ 7.04)	....................clkgqdeqreglltslqnqvnqilsnwreeryqddikarqmmhealqlrlnlvggmfdtvqkstqwttdwallllqiitsgtvdmhtnnelfttvldmlgvlingtlasdlsnaspggseenkraymnlvkklkkelgdkrsESIDKVQQLLPLPKQTCD
 1495- 1531 (36.67/16.26)	IITCEPMGSLIDTkgnkiaG.............................................................................................................................................fDSIDKKQGLQVSTKQK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.04|      13|      19|    1224|    1242|      15
---------------------------------------------------------------------------
 1207- 1222 (16.56/ 9.81)	AEMNNlldNIAKATIE
 1228- 1240 (22.47/11.37)	AELNN...NSSNSGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.36|      18|     217|    1176|    1193|      16
---------------------------------------------------------------------------
 1176- 1193 (33.76/24.37)	QNLEQWTLRQSWLELQLM
 1395- 1412 (32.60/23.22)	QKSTQWTTDWALLLLQII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18551 with Med12 domain of Kingdom Metazoa
Unable to open file!