<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18545

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVLGESGGMQSAASHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQYKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTTGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPNSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYRLPPCEDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSAQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLLMCQTTFLPQAEGTRKSQEPPISLLLLLQSQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNSGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPASSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYSSEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2211
PositionMiddle
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.07
Grand average of hydropathy-0.388
Instability index57.77
Isoelectric point5.64
Molecular weight242786.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18545
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.74|      21|      28|    1596|    1621|       1
---------------------------------------------------------------------------
 1579- 1595 ( 5.16/ 6.21)	...SASGSSvppASSS....ASA...P....
 1601- 1621 (39.63/17.10)	STTSSSGFS...GSVG....GQN...PSTGG
 1623- 1650 (28.95/ 8.75)	STDRTQGNI...GCGGdtdpGQSssqPSQDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      27|      28|    2071|    2098|       2
---------------------------------------------------------------------------
 2071- 2098 (41.86/31.35)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2100- 2129 (46.00/29.09)	YFV.STAKAENLpqwFWSSCPQAQNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.87|      27|      28|    1010|    1036|       3
---------------------------------------------------------------------------
 1010- 1036 (48.71/25.49)	PDYLNTPQMNTPVTLNSAAPASNSGAG
 1041- 1064 (44.66/22.65)	P...ATPRFSVPTPRTPRTPRTPRGGG
 1080- 1098 (26.51/ 9.94)	GSPASTPSTTRP..LNSVEPA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1132|    1158|       4
---------------------------------------------------------------------------
 1132- 1151 (40.30/31.46)	CICACNMNIK.GADVGLYIPD
 1162- 1182 (33.83/12.35)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     321.25|      68|     546|     941|    1008|       5
---------------------------------------------------------------------------
  307-  354 (55.76/22.96)	......VGQQGLGSV...K.DPS.NCGM............PLTPPTS.........PEQAVLG..ESGGMQSAASHLgsQDG...............
  358-  426 (72.32/32.11)	.........TMHSPKrsgKIPPKlHNHM............VHRVWKECIlnrtqYKRSQMSTPTLEEEPASNPATW....DFVDPTQR...VScSCS
  449-  521 (67.56/29.47)	FSagPSSSSSLPPPA...S..SK.HKTTerqekgdklqkrPL.IP..FH.....HRPSVA.....EELCMEQDTTGQ..KLGLAGIDSsleVS.S..
  941- 1008 (125.62/61.54)	FQ..PFVGSSMFAPL...KMLPS.HCLL............PLKIPDACL.....FRPSWAIPPKIEQLPMPPAATFI..RDGYNNVPS...VG.SLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.03|      21|      21|    1524|    1544|       6
---------------------------------------------------------------------------
 1524- 1544 (38.35/19.52)	LIPPKYQTPPAAAQGQATPGN
 1548- 1568 (36.68/18.29)	LAPNSGSAAPPAGSAFNPTSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.11|      12|      24|     543|     554|       7
---------------------------------------------------------------------------
  543-  554 (24.23/11.33)	NPMDSPNSPISP
  569-  580 (22.89/10.21)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.21|      18|      24|    1698|    1717|       8
---------------------------------------------------------------------------
 1698- 1717 (29.95/23.29)	NFWLLSLMRC.YteMLDNLPE
 1721- 1739 (28.26/15.55)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      12|     298|     127|     138|       9
---------------------------------------------------------------------------
  127-  138 (23.47/12.80)	HNLLERCLMDKN
  428-  439 (23.32/12.68)	HKLLKRCAVGPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.56|      27|      29|    1855|    1883|      10
---------------------------------------------------------------------------
 1855- 1883 (43.80/35.48)	C..VVNI.ALPNRSRRSKVSarKIGLQKLWEW
 1884- 1913 (41.76/26.87)	CigIVQMtSLPWRVVIGRLG..RLGHGELKDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.52|      17|     546|      68|      87|      11
---------------------------------------------------------------------------
   68-   84 (33.29/31.10)	LLCVWRRDVKPDCKELW
   94-  110 (29.23/14.67)	LVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.29|      17|      17|    1234|    1250|      12
---------------------------------------------------------------------------
 1234- 1250 (30.27/17.08)	TQPFASLSFLDYISSNN
 1253- 1269 (33.02/19.32)	TLPCVSWSYDRVQADNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.99|      74|    1266|     156|     235|      13
---------------------------------------------------------------------------
  156-  235 (115.18/92.04)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1425- 1501 (124.81/77.85)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.38|      19|      21|     818|     837|      14
---------------------------------------------------------------------------
  818-  837 (27.94/17.51)	DDDELGAVSPALRSSKmPTV
  840-  858 (35.45/18.12)	EDRPLGKDGRAAVPYP.PTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.79|      16|      17|     889|     904|      15
---------------------------------------------------------------------------
  889-  904 (27.46/17.69)	SETVTALGM.MESPMVS
  907-  923 (22.33/12.87)	SAQLTEFKMeVEDGLGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.19|      18|      22|    2001|    2018|      16
---------------------------------------------------------------------------
 1977- 1993 (21.38/10.50)	.TALNMQSS...QLNTPQDAS
 2001- 2018 (31.10/19.50)	PTSSTIQVA...PANYPNEDG
 2021- 2041 (26.70/15.42)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      21|    1340|    1357|      17
---------------------------------------------------------------------------
 1340- 1357 (33.04/20.59)	KKRTGRTWENIQHVQGPL
 1363- 1380 (32.51/20.12)	HKMAGRGTYGSEESPEPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18545 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVP
2) CAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTTGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPNSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
3) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
5) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVLGESGGMQSAASHLGSQDGGMITMHSPKRSGKIPPKLH
6) PPKYQTPPAAAQGQATPGNAGPLAPNSGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPASSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAH
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
804
434
2041
736
305
1526
1004
853
589
2089
802
373
1674
1101










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIW
678
683