<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18544

Description Mediator of RNA polymerase II transcription subunit 13
SequenceSYLEALRTQSFWVFMKASLSNHVVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVLGESGGMQSAASHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQYKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTTGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPNSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYRLPPCEDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSAQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLLMCQTTFLPQAEGTRKSQEPPISLLLLLQSQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNSGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPASSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYSSEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2131
PositionMiddle
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index58.65
Isoelectric point5.69
Molecular weight233868.82
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18544
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.99|      74|    1266|      76|     155|       1
---------------------------------------------------------------------------
   76-  155 (115.18/104.79)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1345- 1421 (124.81/88.66)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.43|      23|      24|    1480|    1502|       2
---------------------------------------------------------------------------
 1480- 1502 (39.36/14.28)	GSAFNPTSNSSSTNPAASSSASG
 1532- 1554 (35.07/11.95)	VGGQNPSTGGISTDRTQGNIGCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     732.26|     140|     141|     434|     573|       3
---------------------------------------------------------------------------
  358-  430 (81.91/34.62)	.....................................P....NRPPTISQ..PGFS.AGP..SSSSSLPPPASSKHKTT.erqeKGDKLQKRPLIPFH.HRPS.VAEEL........................................CMEQDTTGQKLGL
  434-  573 (237.11/116.93)	DSSLEVSS.SRKYDKQMAV.PSRNTSKQMN.LNPMDSP....NSPISPLP..PTLS.PQPRGQETESLDPPSVPVNPAL.....YGNGLELQQLSTLD.DRTVLVGQRLPLMAEVSETALYC..G..IRP..SNPESSDKWWHSYRLPPCEDAEFRPPELQG
  577-  710 (178.92/86.07)	DAKMEVNSeSTALQRLLAQ.PNKRFKIWQD.KQPQMQP....LHFLDPLP....LS.QQP.G...DSLGEVN...DPYT.....FEDG.DIKYIFTAN.KKCKQGTEKDSLKKNKSEDGFGT..KdvTTPghSTPVPDGKNAMSI.FSSATKTDVRQDNAAG
  731-  866 (161.36/76.76)	DNIFDNSD.D...DELGAVsPALRSSKMPT.VGTEDRPlgkdGRAAVPYP..PTVA.DLQRMFPT....PPSLEQHPAFspvmnYKDGISSETVTALGmMESPMVSM.VS..AQLTEFKMEVedG..LGS..PKPEEIKDFSYVHKVPS.....FQP..FVG
  922-  997 (72.95/29.87)	PS...VGS.LADPD.YLNT.PQMNTPVTLNsAAPASNS....GAGVLPSPatPRFSvPTPRT........PRTPRTP.......RGGGTASGQGSVKY.DST............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.08|      23|      26|    1661|    1686|       4
---------------------------------------------------------------------------
 1664- 1686 (45.78/28.01)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1688- 1715 (28.29/ 8.67)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      27|      28|    1991|    2018|       5
---------------------------------------------------------------------------
 1991- 2018 (41.86/34.25)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2020- 2049 (46.00/31.80)	YFV.STAKAENLpqwFWSSCPQAQNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    1940|    1962|       6
---------------------------------------------------------------------------
 1940- 1962 (24.82/26.23)	SPNNDdmfvDLPFPDDmDNDIGI
 1971- 1988 (34.25/17.78)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.34|      12|      27|    1794|    1805|       8
---------------------------------------------------------------------------
 1794- 1805 (24.58/15.76)	KIGLQKLWEWCI
 1824- 1835 (22.75/14.00)	RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.49|      21|      51|    1452|    1474|       9
---------------------------------------------------------------------------
 1452- 1474 (30.88/22.23)	PPAAAQGQAtPGnAGPLAPNSGS
 1506- 1526 (36.62/17.57)	PPASSSASA.PG.ISQISTTSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.08|      17|     136|    1620|    1637|      10
---------------------------------------------------------------------------
 1620- 1637 (26.88/22.20)	WLLSLMRCyTEMLDNLPE
 1643- 1659 (31.20/19.82)	FILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.07|      11|      27|    1556|    1566|      12
---------------------------------------------------------------------------
 1556- 1566 (20.33/ 9.76)	DTDPGQSSSQP
 1585- 1595 (20.74/10.13)	EPDSADSHAHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18544 with Med13 domain of Kingdom Metazoa
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