<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18542
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKEMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQFQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA |
Length | 672 |
Position | Tail |
Organism | Cebus capucinus imitator |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae>
Cebinae> Cebus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.797 |
Instability index | 91.67 |
Isoelectric point | 9.38 |
Molecular weight | 75344.56 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18542
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 116.42| 20| 20| 90| 109| 1
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90- 109 (42.59/ 9.18) QQQQQQQFQQQAALQQQQQQ
176- 195 (36.83/ 6.69) QQQQQQQQQQQQALQAQPPI
223- 242 (37.00/ 6.76) HHQPPPQPQQPPVAQNQPSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 134.96| 34| 36| 334| 369| 3
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269- 308 (43.67/ 6.50) PLKFVRAPMvvQQPQVQPQVQQQTAvqtaQTAQMVAPGVQ
334- 358 (42.81/ 7.73) ...........PPPQPSPQPGQPGS....QPNSNVSSGPA
361- 389 (48.48/12.00) PSSFLPSPS....PQPSQSPVTART....PQNFSV...PS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 66.06| 18| 43| 198| 218| 4
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148- 165 (31.30/ 6.12) HHQNQQQIQQQQ...QQLQRM
198- 218 (34.77/13.09) PPMQQPQPPPSQalpQQLQQM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 69.85| 19| 28| 447| 473| 7
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447- 465 (33.52/29.46) LSKMKSLLDILTDPSKRCP
476- 494 (36.33/14.31) LEKLKNDMAVPTPPPPPVP
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