<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18539

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKEMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTATPQTQLQLQQVALQQQQQQQFQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length783
PositionTail
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.03
Grand average of hydropathy-0.691
Instability index87.73
Isoelectric point9.49
Molecular weight86183.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18539
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     313.94|      42|      42|     174|     215|       1
---------------------------------------------------------------------------
  174-  215 (79.63/15.55)	LQ.QQQQQQ....QFQAQQSAMQQ..QFQAVVQQQQQQLQQQQQQQQHL
  216-  259 (58.85/ 9.25)	IKlHHQNQQ....QIQQQQQQLQRmaQLQ.LQQQQQQQQQQQQQQQQQA
  260-  295 (63.49/10.66)	LQ.AQP.........PIQQPPMQQ..PQPPPSQALPQQL.QQMHHPQHH
  296-  341 (62.13/10.25)	QP.PPQPQQppvaQNQPSQLPPQS..QTQPLVSQAQALPGQMLYTQPPL
  428-  459 (49.84/ 6.52)	LS.SPSPGQ....QVQTPQS.MPP..PPQPSPQPGQPGSQ.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.65|      18|      19|      99|     116|       2
---------------------------------------------------------------------------
   99-  116 (36.18/15.89)	IGMPPRGPGQSLGGMGGL
  119-  136 (34.47/14.77)	MGQPMSLSGQPPPGTSGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.00|      17|     138|     482|     507|       3
---------------------------------------------------------------------------
  476-  493 (29.33/ 9.00)	LPSPSP...qPSQSPVTA...........RTP
  596-  627 (18.67/ 6.01)	VPTPPPppvpPTKQQYLCqplldavlaniRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.05|      29|     151|     543|     577|       4
---------------------------------------------------------------------------
  543-  577 (46.31/35.44)	RMINKIDknedrkKDLSKMKSL.LDILTDPSKRCPL
  700-  730 (43.73/22.32)	HLICKLD.....dKDLPSVPPLeLSVPADYPAQSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.59|      16|     192|     158|     173|       7
---------------------------------------------------------------------------
  158-  173 (28.91/11.16)	VALQQQQQQQFQQQAA
  349-  364 (29.69/11.72)	VVQQPQVQPQVQQQTA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18539 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTAT
2) MLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
70
334
253
148
533
332










Molecular Recognition Features






MoRF SequenceStartStop




NANANA