<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18529

Description Mediator complex subunit 12
SequenceFASPALLSHYLPLRKTKLNDAFLPQDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTGDPFLFFPPEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSMIGPLPHDVEVAIRQWDYNERLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDIEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQYLRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPMLGTQPLNWVGDSMEWGRGGRQGMAPLKGIGRPGVVAHACNPSVLGGRGGWIT
Length2200
PositionKinase
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.07
Grand average of hydropathy-0.469
Instability index56.24
Isoelectric point6.62
Molecular weight244654.86
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18529
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     149.09|      15|      15|    2062|    2076|       1
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 2062- 2076 (35.20/13.38)	QQQQQQQQQQQQQQQ
 2079- 2093 (35.09/13.31)	RQQQQQQQQQQQQQQ
 2094- 2106 (25.88/ 8.03)	QQQQQQQQQQQQQ..
 2107- 2120 (28.51/ 9.54)	.QQQQQQHQQQQQQQ
 2121- 2135 (24.40/ 7.18)	AAPPQPQPQSQPQVA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     327.91|      73|      76|    1853|    1925|       2
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 1761- 1843 (74.24/31.04)	PEKKAPEPPKTDKPgA.....APPSteERKKKSTKGKKRSQP.atktedyGmGPgRSGPY.GVTVP.PDLLHHPN..PG....SI...ThlnyrqGSI.G.L.
 1844- 1891 (73.64/30.73)	........YTQN............................QP.....lpaG.GP.RVDPYRPVRLPMQKLPTRPTY.PGVLPTTM...T......GVM.G.LE
 1892- 1969 (93.53/41.15)	PSSYKTSVYRQQQP.A.....VPQG..QRLRQQLQAKIQSQG......mlG.QS.SVHQMTPS..SSYGLQTSQGYtPYVSHVGLqqhT......GPA.GtMV
 1970- 2048 (86.49/37.46)	PPSYSSQPYQSTHP.StnptlVDPT..RHLQQRPS......GyvhqqaptY.GH.GLTSTQ..RFSHQTLQQTPMI.STMTPMSA...Q......GVQtG.VR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     754.63|     216|     230|     351|     579|       3
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  218-  347 (130.88/70.42)	....................................................................................................................GSMIGPLPHDVEVaIRQWDYnERLAMFMFQ.DGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSNTP...STP
  351-  579 (337.43/237.45)	LLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS..FDKCQEatAGFTIGRVLHTLEV.LDSHSF.ERSDFSNSL.DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ
  582-  815 (286.32/171.81)	MLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEG.KGSPSP.EKPDIEKEVkPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     855|     869|       4
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  855-  869 (26.85/18.74)	LEQITSFALG.MSYHL
  871-  886 (23.14/15.01)	LVQHVQFIFDlMEYSL
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     763.45|     197|     206|    1235|    1438|       5
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 1036- 1232 (216.19/118.21)	........FTYTGLGKSLSENPANR.YSfvcnalmhvcVGHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNngtcgfndllcnvDVS.DLSFHDSLATFVAILI...........A......................RQCL..LLEDLIRCAAIPSLLNAACSEQDS...ePGARLTC..riLLHLFKTPQLNPCQ.......SDGNKPTVGIRSSCDRHLLaASQNRivdGAVFAVLKAVFVL
 1234- 1437 (314.26/191.91)	DAELKGSGFTVTGGTEELPEEEGGG.GS..........GGRRQGGR..NISVETASLDVYAKYVLrsicQQEWVGeRCLKSLCEDSN.............DLQ.DPVLSSAQAQRLMQLI...........CYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMRQSSLELQLMIKQT....PNNEMNS....LLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKAKPVL.SSLER...SGVWLVAPLIAKL
 1438- 1643 (233.00/128.01)	PTSVQGHVLKAAG..EEL..EKGQHlGS..........SSRKERDRqkQKSMSLLSQQPFLSLVL...........TCLK.....GQ.............DEQrEGLLTSLYSQ.VHQIVnnwrddqylddCKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAV....LLLEIIISGTvdmqSNNELFTtvldMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKEL.GERQS...DSLEKVRQLL.PL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.33|      14|      17|    1666|    1682|       6
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 1666- 1682 (16.32/19.37)	KIAGFDsIFkkEGLQVS
 1686- 1699 (28.02/17.27)	KLSPWD.LF..EGLKPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.67|      19|      27|    2143|    2167|       9
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 2143- 2167 (32.26/30.63)	QGqlpMlgtQPLNWVG..........DSMEWGRGG
 2169- 2197 (30.40/13.83)	QG...M...APLKGIGrpgvvahacnPSVLGGRGG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18529 with Med12 domain of Kingdom Metazoa
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