<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18528

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSMIGPLPHDVEVAIRQWDYNERLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDIEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQYLRVRHWDGIWDAGTRGRGEAQVLPTQLPRLNKAVYPNAQQSGWTLVVLEVSYPPPFCFLGIIEGQTWTLSAGYPRFGFFLGSCLRREGSRPQAPSLLPHPLPSALQF
Length2095
PositionKinase
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.07
Grand average of hydropathy-0.433
Instability index52.08
Isoelectric point6.51
Molecular weight233280.62
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18528
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     364.71|      96|     101|    1573|    1673|       1
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 1573- 1671 (163.16/91.03)	LIDTKGNKIAgfDSIFKKE..GLQVSTKQKLS...PWDLFEGLK....PSAPLSWGWFGTV.RVDRRVARGEEQQRLLLYHTHLRP....RP......RAYYLEPLPLPPEdEEPPAPT
 1700- 1789 (126.49/57.42)	KKSTKGKKRS..QPATKTEdyGMGPGRSGPYGvtvPPDLLH..H....PN.P......GSItHLNYR......QGSIGLY.TQNQPlpagGP......RVDPYRPVRLPMQ.KLPTRPT
 1853- 1922 (75.06/33.46)	.....................GLQ..TSQGYT...PYVSHVGLQqhtgPAGTMVPPSYSS...QPYQSTHPSTNPTLVDPTRHLQQ....RPsgyvhqQAPTY................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.05|      57|     231|    1058|    1134|       2
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  262-  325 (90.04/43.92)	CFEK.IRPGEDELLKLLLPLLLRTILLCCPSalvwhySLTDSRIKTGSPLD.HLpIAPSNLPMPEG
 1076- 1134 (94.02/54.88)	CSEQdSEPGARLTCRILLHLFKTPQLNPCQS......DGNKPTVGIRSSCDrHL.LAASQNRIVDG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.87|      47|     231|     429|     553|       3
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  497-  550 (70.98/133.97)	LTDP.RSESERVEFFNLVlLFCELIRHDvFShnMYTCTLISRGDlafGAPGPRPP
  573-  620 (84.88/21.77)	LEDPgLSESMDIDPSSSV.LFEDMEKPD.FS..LFSPTMPCEGK...GSPSPEKP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.68|      32|     231|     429|     493|       4
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  190-  222 (56.58/20.43)	IITKYLwEQLQKMAEYYRPGPA......GSGGCGSMIGP
  440-  477 (47.10/49.38)	VVAKLL.EKRQAEIEAERCGESeaadekGSIASGSLSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     769|     783|       9
---------------------------------------------------------------------------
  769-  783 (26.85/18.00)	LEQITSFALG.MSYHL
  785-  800 (23.14/14.43)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.01|      30|     231|    1283|    1316|      14
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 1283- 1316 (43.27/40.00)	IKQTPnnemNSLLENIAKATIEVFQQSAETGSSS
 1348- 1377 (49.74/34.14)	IAKLP....TSVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      15|     231|    1203|    1232|      15
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 1007- 1021 (30.98/ 9.56)	EWLG..VLKALCCSSNN
 1206- 1222 (26.87/30.59)	EWVGerCLKSLCEDSND
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.51|      24|     202|     828|     855|      17
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  828-  855 (32.93/34.28)	SDLvgSYTTSLClCIVAVLRHYHaCLIL
 1036- 1059 (42.58/25.96)	SDL..SFHDSLA.TFVAILIARQ.CLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.08|      13|      20|    1234|    1251|      18
---------------------------------------------------------------------------
 1234- 1251 (14.31/20.71)	QRlmQLIcypHRLLDNED
 1256- 1268 (23.78/11.14)	QR..QRI...KRILQNLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.99|      17|      20|     962|     978|      21
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  962-  978 (33.37/22.93)	NP..ANRYSFVCNALMHVC
  983- 1001 (26.63/16.74)	DPdrVNDIAILCAELTGYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.33|      23|     148|    1816|    1838|      23
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 1816- 1838 (41.38/22.60)	QQQPAV....PQGQRLRQQLQQSQGML
 1938- 1964 (30.82/14.70)	QQTPMIstmtPMSAQGVQTGVRSTAIL
 1967- 1989 (41.13/22.41)	QQQQQQ....QQQQQQQQQQQQQQQYL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18528 with Med12 domain of Kingdom Metazoa
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