<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18466

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLAEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKDMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVVVPQSDIPTPSSVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQKKRKYSASSGGLCEEETAAKVASWDFVEATQRTNCSCLRLMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADIGVYIPDPAQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLRESEKLPDDLILLLQDQCTNLFSPFGAADQDPFPKSSVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQPLITPSQMANTGNANNPSATLASATSTTMTMTSGVAISTSVATANSALTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANAVQSGQLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIVDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQGTDRLLSTEAHDEVPNILQQPLALGYFVSTAKAGPLPNWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length1897
PositionMiddle
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.08
Grand average of hydropathy-0.322
Instability index51.02
Isoelectric point5.21
Molecular weight208399.01
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18466
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|    1415.89|     276|     278|    1196|    1471|       1
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  537-  702 (148.03/85.69)	................................................................................P....PSTSLIYDSDLAvsytDL.DNLfNSDEDEL.......TPG..................SKKSANGSDDKASC..KESKTGNLdplscistadlhkmypTPPSLEQHIMGFSP.M.NM....NNKEYGSMDT.....................TPGG..TV.LEGNSSSIGAQFKIEVDEGFCS.PK...PSEIK.DFSYVY......KPencQILVgcSMFA.PL...............................................KTLPSQY.LPP.
  704-  886 (190.78/113.26)	.KLPEECIyrQSWtvgkLELLPSGPAMP...FIKEGDGSNM.DQEYGP..A...Y..T.....PQTHTSFGM...P....P....SSAP...PS.......NS.GAG.ILPSPSTprfptprTPRTPRTPRGAGGPAsA..QGSVKYENSDLYSPAS..TPSTCRPL................NS.VEPATVPSIPE.AHSL....YVNLI..................................................LSESVMNLFK...DCNFD.SCCICVcnmnikGA...DIGV..YIPD.P............................................................
  914- 1186 (345.41/213.01)	..LEDEL....DI....IGRNTDCGKEAekrFEALR..ATSAEHVNGGLRE...SekL.....PDDLILLLQdqcTNLFSPfgaaDQDPFPKSSVIS....NW.VRV.EERD...........CCNDCYLALEHGRQ.FmdNMSGGKVDEALVKSSClhPWSKRNDV................SMQCSQDILRMLLS.LQPV....LQDAIQKKRTVRPWGVQGPL.....TWQ...QFHKMAGRGSYGTDESPEPLPIPTFLLG.YDYDYLVLS.....PFALPY......WE...RL.....MLE.PYG.SQRDIAYVVLC.......PENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDG
 1196- 1471 (442.80/275.84)	KKLSEKLV..AEW....FSQAADGNNEA...FSKLKLYAQVCRYDLGPYLA...S..L.....PLDSSLLSQ...PNLVAP....TSQPLITPSQMA....NT.GNA.NNPSATL.......ASATSTTMTMTSGVA.I..STSVATANSALTTAST..SSSSSSNL................NSGVSSNKLPSFPP.FGSM....NSNAAGSMSTQANAVQSGQL.....GGQ...QPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGD.SHAITY......PP...AIVV..YIVD.PFTYENKDESTNSSN.......VWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPV
 1481- 1747 (288.88/176.55)	QHL.KSLA..FSA....FTQCRRPLPTS....TNVKTLT.....GFGPGLAmetA..LrspdrPECIRLYAP...PFILAP....VKD...KQTELG....ETfGEA.GQKYNVL.......FVGYCLSHDQR...W.I..LASCTDLYGELLETCI..INIDVPNW................SCLLSRRNLQSLSKrLKDMcrmcGISAADSPS.....ILSACLvamepQGSfviMPDSVSTGSVFGRSTTLN...........MQTSQLNTPQDTScTHILVF......PT...SASV..QVASaTYTTENLDLAFNPNNdgadgmgIFDL......LDTGDDLDPDI.....INILPASPTGSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     382.03|     121|     281|       6|     160|       2
---------------------------------------------------------------------------
    6-  149 (197.09/152.16)	VPNGASLEDCHCNLFCLadltGIKWKryvwqgptsapilfPVTEEDPILSSFSRCLKADVLGVWRRDqrPGRRELWIFWWGEDPNF.AD.LIHH......DLAEE.EDGVW.ENGLSYECRTLLFKAVHNLLerClMNRNFVRIGKW.FVKPYEK
  290-  421 (184.93/99.95)	IPTPSSVGSTHCSSSCL....GVHQV..............PASTRDPAMSSVTLTPPTSPEEVQTVD..PQSAQKWVKFSSVSDGFnSDsTSHHggkiprKLANHvVDRVWqECNMNRAQKKRKYSASSGGL..C.EEETAAKVASWdFVEATQR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18466 with Med13 domain of Kingdom Metazoa
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