<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18447

Description Mediator of RNA polymerase II transcription subunit 1
SequenceHGETPFLLKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLISCLETLQKALKGFCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHESNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLATGDLGKEKTQKRAKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1517
PositionMiddle
OrganismCebus capucinus imitator
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Cebinae> Cebus.
Aromaticity0.05
Grand average of hydropathy-0.685
Instability index53.63
Isoelectric point9.10
Molecular weight161548.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18447
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     425.08|      50|      50|    1016|    1065|       1
---------------------------------------------------------------------------
  916-  962 (56.81/13.87)	STLSG........PGLDSK....PGKR.......SRTPSNDGKSKDKP..PKRKKADTEGK.SPS...HSSS
  967- 1014 (45.11/ 9.07)	TPPTS........TG.........GSKSP....GSSGRSQTPPGVATPpiPKITIQIPKGTvMVG...KPSS
 1016- 1065 (83.32/24.73)	SQYTS........SGSVSS....SGSKSH....HSHSSSSSSSSASTS..GKMKSSKSEGS.SSS...KLSS
 1066- 1105 (53.53/12.52)	SIYSS........QGS.SG....SGQSKN....SSQSGGKPGSSPIT..........KHGL.SSS...S.SS
 1106- 1159 (47.43/10.02)	TKMKP........QGKPSSlmnpSLSKPNispsHSRPPGGSDKLASP.....MKPVPG.TP.PSS...KAKS
 1160- 1193 (39.68/ 6.85)	...............PISS....GSGGSH....MSGTSSS.......S..G.MKSSSGLGS.SGS....LSQ
 1201- 1248 (49.54/10.89)	SCTAS........SSSFSS....SGS.SM........SSSQNQHGSSK..GKSPSRNKKPS.LTAvidKLKH
 1249- 1306 (49.66/10.94)	GVVTSgpggedpmDGQMGV....STNSSS....HPMSSKHNMSGGEFQ..GKREKSDKDKS.KVS...TSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     207.54|      49|      50|     259|     308|       2
---------------------------------------------------------------------------
  233-  257 (27.83/ 9.58)	.....................DLPACFFL.KFPQPIPVSRA...F...VQKL...Q..
  259-  308 (89.31/51.62)	CTGI....PLFETQPTYVPLYELITQFELSKDPDPIPLNHNM.RF...YAALPGQQhC
  310-  359 (50.34/23.58)	..FLnkdaPLPDGRSLQGTLVSKIT...F.QHPGRVPLILNLiRHqvaYNTLIGS..C
  369-  397 (40.06/17.06)	SPGL....LQFEV....CPLSE..SRFSVSFQH...PVNDSL................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     285.45|      63|      64|     503|     565|       3
---------------------------------------------------------------------------
  503-  535 (44.11/14.82)	.........................................P..GGPITTL.......FNM.SMS.I.KDRHESVGHGED..F.SKVSQ
  536-  592 (73.10/30.39)	NPILTSLLQITGNGGST..IGSSP....TPPHHTPPpvssmA..GN..TKN.......HPM.LMNlL.KD...N..PAQD..F......
  656-  715 (55.08/20.71)	NPIFDV..NMTADTLDTphITPAPsqcsTPPTTYPQ......pvPHPQPSI.......QRMvRLS.S.SD...SI..GPD..V.T....
  716-  762 (48.73/17.30)	.DILSDIAEEASKLPST....SDD....CPAIGTP................................lRDSSSS.GHSQStlFdSDVFQ
  768-  823 (64.43/25.74)	NPYTDPADLIADAAGSP....SSD....SPTNH..................ffhdgvdFNP.DL..L.NSQSQS.GFGEE.yF.DESSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.26|      40|      51|    1333|    1381|       4
---------------------------------------------------------------------------
 1333- 1362 (39.45/15.91)	...............H...............DGG.....................SPSIKAKVTLQKPgESSGEGLRPQMA
 1371- 1424 (44.24/25.70)	LISGSTPKHERgspsHskspaytpqnldsesESG.....................S.SIAEKSYQNSP..SSDDGIRP...
 1425- 1483 (56.57/19.54)	LPEYSTEKHKK....H...............KKEkkkvkdkdrdrdrdkdrdkkkSHSIKPESWSKSP.ISSDQSL..SMT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.37|      12|      22|     825|     837|       5
---------------------------------------------------------------------------
  825-  837 (20.49/15.50)	GDNDD..FKGfASQA
  848-  861 (19.88/ 9.60)	GDNGEtkFKG.NSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.91|      20|      32|     174|     193|       7
---------------------------------------------------------------------------
  174-  193 (33.72/18.00)	PIILHESNVSRSLGMN.ASVT
  207-  227 (33.19/17.59)	PLIMGSHPVDNKWTPSfSSVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.19|      46|      50|      60|     109|       8
---------------------------------------------------------------------------
   60-  109 (69.88/55.77)	ETLQKALKGFCpelVQQLREKNFDEFSKHLKGLVNlYNLP..GDNKLKTKMY
  113-  160 (77.30/48.86)	QSLEQDLSKMA...IMYWKATNAGPLDKILHGSVG.YLTPrsGGHLMNLKYY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18447 with Med1 domain of Kingdom Metazoa
Unable to open file!