<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18433

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQVGIVVLFIFSFTLSDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVFLRAFVLFPRVNDIAILAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKGLGSGPRLRGRKEKSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTLPPSAPSEQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVATGLEPQAQGQLPRLGMQPVNWVGDSME
Length2145
PositionKinase
OrganismCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Cercocebus.
Aromaticity0.07
Grand average of hydropathy-0.435
Instability index54.07
Isoelectric point6.61
Molecular weight238404.30
Publications









Function






Annotated function


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18433
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     102.91|      15|      15|    2069|    2083|       1
---------------------------------------------------------------------------
 1946- 1959 (20.93/ 6.65)	TPSSSYGLQ.TSQGY
 2069- 2083 (28.98/12.20)	QQQQQQQQQQQQQQQ
 2085- 2099 (29.36/12.46)	QQQQQQQQQQQHQQQ
 2114- 2128 (23.63/ 8.51)	QPQVATGLEPQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.79|      16|      20|    1755|    1774|       2
---------------------------------------------------------------------------
 1755- 1770 (29.13/ 7.45)	PLPPEDEEPPA..PTLLE
 1776- 1793 (22.66/ 8.70)	PEPPKTDKPGAapPSTEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.76|      13|      17|    1459|    1473|       3
---------------------------------------------------------------------------
 1459- 1473 (18.90/16.45)	GQHLgsSSRKERDRQ
 1479- 1491 (23.86/13.14)	GPRL..RGRKEKSQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.83|      69|     234|    1147|    1220|       4
---------------------------------------------------------------------------
 1147- 1220 (105.25/92.44)	LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRI
 1383- 1456 (97.59/66.60)	LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      16|     867|     881|       5
---------------------------------------------------------------------------
  867-  881 (26.85/17.26)	LEQITSFALG.MSYHL
  883-  898 (23.14/13.84)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     140.14|      29|     353|     321|     359|       6
---------------------------------------------------------------------------
  331-  359 (52.47/35.32)	SHVISAQST....SSLPTTPAPQPPTSSTPST.P
 1964- 1997 (49.43/17.62)	SHVGLQQHTgpagTMVPPSYSSQPYQSTHPSTnP
 2032- 2062 (38.24/10.80)	SHQTLQQ.TpmisTMTPM..SAQGVQAGVRSTlP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     103.11|      21|      21|    1836|    1856|      11
---------------------------------------------------------------------------
 1818- 1837 (20.55/ 8.28)	PG...........RSGPYGVTVP..pdllhhPN
 1838- 1860 (32.65/18.68)	PGSIT...HLN.YRQGSIGLYTQ......nqPL
 1861- 1888 (22.21/ 9.70)	PAGGP...RVDpYR..PVRLPMQklptrptyPG
 1891- 1914 (27.71/14.43)	PTTMTgvmGLE.PSSYKTSVYRQ........QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.69|     100|     231|     527|     635|      12
---------------------------------------------------------------------------
  527-  635 (145.60/112.28)	SCKRSGRHRAMVVAKLLEKR.QAEIEAERCGES..EAADEKGSIASGSLsAPSAPIfQDVLLQFL...DTQAPMLTDPRSESERVEFFNlvlLFCELIRHDvfSHNMytCTLISR
  759-  864 (157.09/93.69)	SCSHECNQRLVVLFGVGKQRdDARHAIKKITKDilKVLNRKGTAETDQL.APIVPL.NPGDLTFLggeDGQKRRRNRPEAFPTAEDIFA...KFQHLSHYD..QHQV..TAQVSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1573|    1586|      13
---------------------------------------------------------------------------
 1573- 1586 (24.50/18.66)	LLEIIISGTV..DMQS
 1597- 1612 (20.20/13.81)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      16|    1333|    1347|      14
---------------------------------------------------------------------------
 1333- 1347 (21.57/15.53)	HRLLDNEDgENPQRQ
 1350- 1363 (26.45/14.12)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.74|       9|      16|    1041|    1050|      15
---------------------------------------------------------------------------
 1041- 1050 (13.93/11.91)	ENPaAHTFTY
 1059- 1067 (17.81/ 9.92)	ENP.ANRYSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.94|      14|      18|    1672|    1689|      16
---------------------------------------------------------------------------
 1672- 1689 (13.23/21.86)	TKgNKIAGFDsIFkkEGL
 1693- 1706 (28.71/17.37)	TK.QKISPWD.LF..EGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      15|     198|    1096|    1110|      17
---------------------------------------------------------------------------
 1096- 1110 (30.98/21.14)	EWLG..VLKALCCSSNN
 1295- 1311 (26.87/17.22)	EWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.44|      10|      18|     366|     377|      20
---------------------------------------------------------------------------
  366-  377 (16.13/14.98)	CPQhrPLVFGLS
  387-  396 (22.31/12.25)	CPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      22|      22|    1623|    1644|      25
---------------------------------------------------------------------------
 1623- 1644 (34.88/19.23)	RAYMNLAKKLQKELGERQSDSL
 1648- 1669 (37.82/21.49)	RQLLPLPKQTRDVITCEPQGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.92|      19|     627|      16|      35|      26
---------------------------------------------------------------------------
   16-   35 (34.52/22.73)	RPRlGPPDVYPQDPKQKEDE
  646-  664 (38.41/21.15)	RPP.SPFDDPADDPEHKEAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18433 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
2) GAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSV
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSA
4) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTLPPSAPSEQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVATGLEPQAQGQLPRLGMQPVNWVGDSME
5) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
6) VLKAAGEELEKGQHLGSSSRKERDRQKGLGSGPRLRGR
701
641
15
1900
1747
1448
740
688
59
2145
1898
1485










Molecular Recognition Features






MoRF SequenceStartStop




1) ERKKK
2) MAAFGI
1793
1
1797
6