<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18427
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA |
Length | 678 |
Position | Tail |
Organism | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Cercocebus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.814 |
Instability index | 92.37 |
Isoelectric point | 9.38 |
Molecular weight | 76052.30 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18427
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 338.31| 80| 81| 69| 148| 2
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69- 139 (115.92/21.83) ............IHNK...............KSQASVSAQLQLQQVA.LQQQQQQQQFQQQQ......QAALQQQQQQQQQQFQA....QQSAMQ..QQFQAV...VQQQQQQL
140- 221 (124.89/24.25) QQQQQQQQHlikLHHQ...............NQQQIQQQQQQLQRMAqLQLQQQQQQ..QQQ......Q....QQQQQQQQALQAqppiQQPPMQ..QPQPPP...TQALPQQL
222- 320 (97.50/16.86) QQMHHPQHH.......qpppqpqqppvaqnqPSQ..LPPQSQTQPLV.SQAQALPGQMLYTQpplkfvRAPMVVQQPPVQPQVQ.....QQTAVQtaQAAQMVapgVQVSQSSL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 237.08| 44| 45| 325| 369| 3
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325- 368 (88.34/27.51) SPSPGQQVQTPQSMPPPPQPSPQPGQPGSQP.....NSNVSSGP..AP.SPS
373- 406 (44.93/ 9.59) SPSP.QPSQSPVTARTP........QNFSVP.........SPGPlnTPvNPS
486- 527 (51.54/13.68) ..KNDMAVPTP...PPPPVP.PTKQQYLCQPlldavLANIRS.P..VF.NHS
587- 624 (52.26/12.30) HCSNNGTVHLICKLDDKDLPSVPPLE.LSVP.........ADYP..AQ.SP.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.30| 16| 36| 423| 439| 4
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423- 439 (23.61/20.45) LDKLKQLSKYIePLRRM
460- 475 (28.69/19.55) LDILTDPSKRC.PLKTL
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