<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18424

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRLALPGPHPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length756
PositionTail
OrganismCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Cercocebus.
Aromaticity0.03
Grand average of hydropathy-0.703
Instability index85.09
Isoelectric point9.51
Molecular weight83650.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18424
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     303.96|      43|      43|     167|     209|       1
---------------------------------------------------------------------------
  165-  205 (67.06/11.37)	..AAL.......QQQQQQQQQQFQ..AQ......QSAMQQQF.....QAVVQQQQQQLQQQQQ
  206-  251 (55.76/ 8.06)	QQQHLiklhhqnQQQIQQQQQQLQrmAQ......LQ.LQQQ..........QQQQQQQQQQQQ
  252-  287 (68.08/11.67)	QQQAL.......QAQP.......P..IQ......QPPMQQPQ.....PPPTQALPQQLQQMHH
  316-  356 (51.66/ 6.85)	TQPLV.......SQAQALPGQMLY..TQpplkfvRAPM...........VVQQP..PVQPQVQ
  394-  438 (61.40/ 9.71)	PTTAV.......S...AVPSSSIP..LG......RQPMAQVQtpqsmPPPPQPSPQPGQPGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.70|      23|     138|     455|     489|       2
---------------------------------------------------------------------------
  288-  312 (45.38/ 8.52)	PQHHQ.PPPQPQQPPVaqNQPSQLPP
  466-  489 (41.32/21.49)	PQNFSvPSPGPLNTPV..NPSSVMSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     304.21|      79|     121|     515|     593|       4
---------------------------------------------------------------------------
   68-  121 (49.15/15.32)	...DIHPMNALQSLTGGPAagaagigmpPRGPGQ.SLG.GMG.SLGAMGQ....PMSLSG..QP.PP................................
  527-  593 (108.25/42.89)	RKKDLSKMKSLLDILTDPS.........KRCPLK.TLQ.KCEIALEKLKN....DMAVPT..PP.PPPVPPTKQ.QYLCQPLLDAV.............
  604-  650 (54.71/17.91)	.................................H.SLY.RTFV..PAM.......TAIHG..PPiTAPVVCTRK.R....RLEDDERQ.SIPSVLQGEV
  651-  733 (92.10/35.35)	ARLD...PKFLVNL..DPS.........H.CSNNgTVHlICKLDDKDLPSvpplELSVPAdyPA.QSPLWIDRQwQYDANPFLQSVHRcMTSRLLQLPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18424 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) MLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRLALPGPHPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
74
330
249
138
506
328










Molecular Recognition Features






MoRF SequenceStartStop




NANANA