<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18423
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA |
Length | 789 |
Position | Tail |
Organism | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Cercocebus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.703 |
Instability index | 88.63 |
Isoelectric point | 9.49 |
Molecular weight | 86864.66 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18423
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 364.12| 43| 43| 177| 219| 1
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150- 181 (52.42/ 8.17) ...QTQLQ.LQ......QVALQQ......QQQQQQFQQQQQ..AA...L.......QQQQ
182- 231 (74.41/15.53) QQQQQQFQ.AQ......QSAMQQQFQAVVQQQQQQLQQQQQQQQH...LiklhhqnQQQI
232- 270 (63.69/11.94) QQQQQQLQrMA......QLQLQQQ.....QQQQQQQQQQQQQQQA...L.......QAQP
271- 309 (57.31/ 9.81) .......P.IQ......QPPMQQPQPPPTQALPQQLQQMHHPQHHqppP.......QPQQ
335- 375 (49.94/ 7.34) ALPGQMLY.TQpplkfvRAPM......VV..QQPPVQPQVQQQTA...V.......QTAQ
437- 474 (66.35/12.83) PSPGQQVQ.TP......QS.M....PPPPQPSPQPGQPGSQPNSN...V.......SSGP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.16| 17| 21| 86| 106| 2
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86- 102 (32.30/ 9.22) QSLTGGPAAGAAGIGMP
108- 124 (31.86/ 8.92) QSLGGMGSLGAMGQPMS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 85.05| 28| 93| 398| 436| 3
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401- 436 (35.04/30.92) RFPPTTavsAVPSSSiPLGrQPmaqVSQSSL..PMLSS
497- 526 (50.01/15.52) RTPQNF...SVPSPG.PLN.TP...VNPSSVmsPAGSS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 140.88| 33| 151| 549| 583| 5
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550- 583 (53.04/29.57) MINKIDKNEDrKKDLSKMKSL.LDILTDPSKRCPL
586- 611 (42.03/19.74) L....QKCEI...ALEKLKND.MAVPTPPPPPVP.
707- 736 (45.81/19.59) LICKLD.....DKDLPSVPPLeLSVPADYPAQSPL
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