<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18363
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVVCVVDISLESVGFMEKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNGKTLILKELKILFGAQVAFNFWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGSKNPELGSG |
Length | 544 |
Position | Middle |
Organism | Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Cercopithecinae> Cercocebus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.125 |
Instability index | 47.61 |
Isoelectric point | 7.57 |
Molecular weight | 60357.12 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18363
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 204.66| 48| 53| 343| 395| 1
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287- 309 (22.99/ 6.11) ............LPA...CF...FLKFPQP..IP.VSRAFVQKL...............
315- 342 (48.48/21.64) IPLFETQPTYAPLYELITQF...ELSKD........................PD....P
343- 395 (78.90/49.62) IPLNHNMRFYAALPGQQHCY...FLNKDAP..LP.DGRSLQGTLVSkITFQHPGrvplI
396- 445 (54.28/24.01) LNLIRHQVAYNTLIGS..CVkrtILKEDSPglLQfEVCPLSESRFS.VSFQHP......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 122.74| 37| 48| 150| 187| 2
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150- 187 (60.44/46.11) NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
200- 238 (62.30/42.85) NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
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