<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18358

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSISSEHREAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSATPRPVDEPAIKRSRTAGPAVHFKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGHGPDACVTSRAAEEAPAFVQLGPWPTYRPPRTPRSLDHPHPEDHLTARGPRGPWGDPARAPASVSLPLLPRALNLDKLQLGRAGPINALCAHNLGAAPNKRPGPAHNLGVVPGSLCPLGLSLNQYLWGT
Length959
PositionTail
OrganismCercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Cercocebus.
Aromaticity0.06
Grand average of hydropathy-0.010
Instability index48.34
Isoelectric point8.19
Molecular weight105311.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18358
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.92|      20|      27|     692|     714|       1
---------------------------------------------------------------------------
  692-  714 (32.93/23.46)	LLTKLWICCRDEGPASepdEALV
  720-  739 (37.00/18.37)	LPSQLLIPSLDWLPAS...DGLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.39|      48|     134|     744|     791|       2
---------------------------------------------------------------------------
  744-  791 (88.81/51.26)	PKQPLRLQFGRAP...TL..PGSAATLQ....LDGL.ARAPGQPKIDHLRRLHLGACP
  843-  886 (49.80/25.14)	EEAPAFVQLGPWP...TYrpPRTPRSLDhphpEDHLtARGPRGPWGD...........
  888-  928 (54.78/28.48)	.........ARAPasvSL..PLLPRALN....LDKL.QLGRAGP.INALCAHNLGAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.22|      18|     134|      22|      48|       3
---------------------------------------------------------------------------
   23-   40 (37.92/28.11)	KWSKSTHCPSVPLACAWS
  822-  839 (38.30/10.10)	RWIKNCLCGHGPDACVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     643.56|     181|     290|     134|     331|       4
---------------------------------------------------------------------------
   83-  242 (184.02/156.83)	.........................................AIT.........CLEW...DQSGSRLL..SADADGQIKCW.SM.ADH..L.ANSW..ESSVGSLVeGD.pivaLSWlhngVKLALhvEkSGASSFGeKFSRVKFSPSLtlfgGKPMEGWIA............VTVSGLVTVS...........................................L.LKPSG.QVLTSTESLC.RL.....RGRVALADIAFTgggNIVVATADGSSASPVQFY
  243-  377 (207.03/138.13)	KVCVSVVSEKCRID.TEILPSL....FMRCTtdLNRKDKFPAIT.........HLKFLARDMSEQVLLCASSQTSSIVECW.SLRKEG..LPVNNI..FQQISPVV.GDkqptiLKW...........R...........................................................................................................ILSATNDLD.RV.....SA.VALPKLP......ISLTNTDLKVASDTQFY
  388-  542 (176.86/111.82)	DGSVHIVH...RLS.LQTMAVF....YSSAT...PRPVDEPAIKrsrtagpavHFKAM.......................................................qLSW....TSLAL....VGIDNQG.KLSVLRLSPSM....GHPLEVGLAlrhllflleycmVTGYDWWDIL...........................................LhVQPS..MV....QSLVeKLheeytRQTAALQQVLST...RILAMKASLCKLSPCTVT
  543-  681 (75.64/42.14)	RVC.DYHTKLFLIAiSSTLKSLlrphF......LNTPDKSPG................DR.LTE...ICAKITDVDIDKVMiNLKTEEfvLDMNTLqaLQQLLQWV.GD...........................................................................fvlyllaslpnqgsllrpghsflrdgtslgmlrelmvviriwgL.LKPSClPVYTATSD...........................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18358 with Med16 domain of Kingdom Metazoa
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