<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18320

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQSQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGTASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length747
PositionUnknown
OrganismColobus angolensis palliatus (Peters' Angolan colobus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Colobus.
Aromaticity0.05
Grand average of hydropathy-0.250
Instability index60.68
Isoelectric point8.61
Molecular weight78152.81
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl
transcription regulator complex	GO:0005667	IEA:Ensembl

GO - Biological Function
retinoid X receptor binding	GO:0046965	IEA:Ensembl

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18320
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     316.19|      48|      60|     614|     661|       1
---------------------------------------------------------------------------
  189-  235 (45.81/ 7.75)	PALR.LLFEKAA.....P...PAlLEPL...QPPTDV..SQDPRHmvlvrGLVL.PVG..GG....SA
  236-  282 (52.10/10.19)	PG....PLQPKQP...VP..lPP.AAPS...GATLSA..A.PQQP.....LPPVPPQYqvPGnlsaAQ
  604-  643 (79.07/20.63)	.Q.......PQPQGTAQP...PP.GAPQ...GPPGTA..SGPPPP.....GPILRPQN..PG....AN
  644-  688 (69.90/17.08)	PQLRSLLLNPPPPQTGVP...PP.QASLhhlQPPGAP..ALLPPP..........HQG..LG.....Q
  689-  734 (69.31/16.85)	PQLGPPLLHPPPAQS.WPaqlPP.RAPL.....PGQMllSG.GPR.....GPV..PQ...PG....LQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.68|      16|      20|     300|     319|       2
---------------------------------------------------------------------------
  300-  317 (26.20/ 6.78)	GprFSPITPLQQAAPGVG
  375-  390 (27.49/ 7.81)	G..VSGPSPAQLGAPALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.82|      31|     110|      39|      69|       3
---------------------------------------------------------------------------
   39-   69 (58.34/33.26)	YLLPAIEYFNGGPPAETDFGGDYG..GTQYSLV
  151-  183 (50.47/27.77)	YLLPAVESTTYSGCTTENLVQQIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.84|      18|      20|     335|     353|       4
---------------------------------------------------------------------------
  335-  353 (33.30/11.24)	APKPPPASqPSLVSTVAPG
  357-  374 (33.54/ 8.20)	APTAQPGA.PSMAGTVAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     464|     487|       5
---------------------------------------------------------------------------
  464-  487 (34.11/30.89)	LFrnSRMVQF.HFTNKDLESLKGLY
  493-  515 (37.50/26.26)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.56|      30|     106|     430|     463|       7
---------------------------------------------------------------------------
  430-  463 (51.47/39.53)	QVYVNHG..ENLKTEQWPQKLIMQLIPqqllTTLGP
  539-  570 (50.09/29.10)	QVITNHKqvQQQKLEQQQRGMGGQQAP....PGLGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18320 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQSQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGTASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
232
544
390
745










Molecular Recognition Features






MoRF SequenceStartStop




1) LMDLI
743
747