<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18317

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDITPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKESDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVLNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQLHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVSKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2173
PositionMiddle
OrganismColobus angolensis palliatus (Peters' Angolan colobus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Colobus.
Aromaticity0.08
Grand average of hydropathy-0.387
Instability index53.12
Isoelectric point5.38
Molecular weight239290.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18317
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.50|      42|      61|     462|     505|       1
---------------------------------------------------------------------------
  462-  505 (69.10/42.51)	EKSEKPQKRPLTPfhHRVSVSDDVGMDTDSA..SQRLV.ISAPDSQV
  525-  569 (73.40/39.09)	EMANSPQPPPLSP..HPCDVVDEGVTKTPSTpqSQHFYqMPTPDPLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     499.29|     216|     533|     926|    1309|       2
---------------------------------------------------------------------------
  286-  433 (108.72/28.34)	PQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSsvtlTP..PTSPEEVQtvDPQSAQKWVKFSSvSDGFNSDST..........................................................shhggkiprklanhvvdrvwqecnMNraqnkRKYSASSGGLCEE.......AT.AAKVASWDFvEATQRTNCsclRHKN..LK....................................................................................................................................
  977- 1046 (60.56/340.59)	PQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPR....TPrtPRTPRGAG..GPASAQGSVKYEN.SDLYSPAST.................................................................................................................................................................................................................................................................................
 1129- 1300 (198.58/23.82)	.............................................................................pstcrplnsvepatvpsipeahslyvnlilsesvlnlfkdcnfdsccicvcnmnikgadvgvyipdptqeaqyrctcgfsaiMN.....RKFGNSSGLFLEDeldiigrNTdCGKEAEKRF.EALRGTSA...EHVNggLKESEKLSDDLILLLQDqctnlfSPFGAADQDP...FPKSGVISnwvrveeRDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHP.....WSKRNDVSMQCSQdILRMLLSLQ.PVLQ.DAIQKKRTVRP
 2000- 2119 (131.43/ 0.00)	........................................................................................................................................................................................................................LDTGDDLDPDIINILPA......SPTGSPVHSPgshYPHGGDVS.......KGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPlpdwfWSACPQAQYQCPL.FLKASLHLHvPSVQsDELLHSKHSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.37|      61|      67|     793|     856|       3
---------------------------------------------------------------------------
  793-  856 (102.04/66.83)	LTP.GSKKSANGSDDKASCK.ESKTGNLDPLSCiSTADLHKMYptPPSLEQHIMG...FSPMNMNNKEY
  861-  926 (95.33/52.86)	ITPgGTVLEGNSSSIGAQFKiEVDEGFCSPKPS.EIKDFSYVY..KPENCQILVGcsmFAPLKTLPSQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.21|      29|     737|     745|     778|       4
---------------------------------------------------------------------------
  745-  778 (45.35/39.35)	SLFSpsikqDAPRP.ASHARPPSTSLIYDSDLAVS
 1471- 1492 (32.50/16.70)	SLLS........QP.NLVA.PTSQSLITPPQM...
 1497- 1522 (28.37/11.77)	.........NANTPsATLASAASSTMTMTSGVAIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.95|      19|     737|     942|     960|       5
---------------------------------------------------------------------------
  942-  960 (34.80/18.90)	WTVGKLE.LLSSGSAMPF.IK
 1661- 1681 (28.15/13.85)	WTLGLLRcFLEMVQTLPPhIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.57|      51|     531|    1066|    1122|       6
---------------------------------------------------------------------------
 1066- 1122 (84.60/58.55)	EAHSLYVNL..ILSESVLNLFK...DCNFDSCCIcvcnmNIKGADVgVYIPDP.TQEAQYRCT
 1599- 1655 (77.97/39.76)	ESSSLPTQLhpDVSESTMDRDKvgiPTDGDSHAI.....TYPPAIV.VYIIDPfTYENTDEST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.87|      96|    1060|     625|     727|       7
---------------------------------------------------------------------------
  625-  727 (154.94/114.08)	VEFLPPQ..LPSDKFKDDPVGPfgQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPK.IDPYAfvegdEEFLFPDKKDRQN..SER..EAGKKHKV
 1686- 1788 (150.93/94.26)	VQIIPCQylLQPVKHEDREIYP..QHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPEcIRLYA.....PPFILAPVKDKQTelGETfgEAGQKYNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      24|    1327|    1348|       8
---------------------------------------------------------------------------
 1327- 1348 (42.16/24.47)	P..EPLPIPTFLLGYDYDYLVLSP
 1352- 1375 (36.97/20.49)	PywERLMLEPYGSQRDIAYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.05|      46|    1218|     167|     236|       9
---------------------------------------------------------------------------
  167-  236 (66.68/90.44)	FLHGDSNVCTSVEINQHQPV.YLLSEEHITLAQQSnspfqvilcpfglngtltgqafkmSDSATKKLIGEW
 1387- 1433 (75.38/49.63)	FFRDLTAIYESCRLGQHRPVsRLLTDGIMRVGSTA........................SNKLSEKLVAEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.83|      46|     349|    1530|    1593|      11
---------------------------------------------------------------------------
 1548- 1593 (79.35/58.44)	GVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTS.TLQT
 1899- 1945 (74.47/30.49)	GISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTlNMQT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18317 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CLRHKNLKSRNAGQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
2) PFIKESDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
3) SPVHSPGSHYPHGGDVSKGQSTDRLLSTEPHE
4) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQLHPDVSESTMDRDKVGIPTDGD
5) VAPTSQSLITPPQMTNTGNANTPSATLASAA
426
957
2021
1530
1479
586
1038
2052
1628
1509










Molecular Recognition Features






MoRF SequenceStartStop




NANANA