<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18316

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length1988
PositionKinase
OrganismColobus angolensis palliatus (Peters' Angolan colobus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Colobus.
Aromaticity0.07
Grand average of hydropathy-0.510
Instability index58.23
Isoelectric point6.51
Molecular weight221920.83
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18316
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     193.53|      15|      15|    1861|    1875|       1
---------------------------------------------------------------------------
 1861- 1875 (36.66/16.42)	QQQQQQ....QQQ....QQQQQQ
 1878- 1896 (31.06/12.66)	QQQQQQ....QQQyhirQQQQQQ
 1899- 1913 (35.70/15.78)	RQQQQQ....QQQ....QQQQQQ
 1914- 1928 (36.00/15.98)	QQQQQQ....QQQ....QQQQHQ
 1929- 1943 (30.38/12.20)	QQQQQQ....AAP....PQPQPQ
 1944- 1962 (23.73/ 7.73)	SQPQFQrqglQQT....QQQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.53|      16|      17|    1602|    1617|       2
---------------------------------------------------------------------------
 1571- 1587 (22.50/ 8.14)	KKAPePPKTDKPGAAPP
 1602- 1617 (30.04/13.54)	RSQP.AAKTEDYGMGPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.04|      16|      17|     638|     654|       3
---------------------------------------------------------------------------
  638-  654 (24.14/17.60)	DDPADDpEHKEAEGSSS
  658-  673 (28.90/15.74)	EDPGLS.ESMDIDPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      17|     859|     875|       4
---------------------------------------------------------------------------
  863-  875 (24.86/23.39)	MSYHLPLVQHVQF
  880-  892 (22.52/ 8.04)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1027|    1039|       5
---------------------------------------------------------------------------
 1027- 1039 (25.11/13.46)	ENPAA.HTFTYTGL
 1045- 1058 (21.03/10.19)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.89|      15|      18|    1766|    1781|       6
---------------------------------------------------------------------------
 1631- 1644 (20.66/ 7.36)	LH.HPNP.GSITHLNY
 1689- 1703 (16.80/ 8.28)	PTtMTGVMG.LEPSSY
 1766- 1778 (23.43/ 9.13)	...HTGPAGTMVPPSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1470|    1488|       7
---------------------------------------------------------------------------
 1470- 1488 (14.83/25.22)	TKgNKIAGFDsIFkkEGLQ
 1491- 1505 (30.03/20.12)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.51|      16|      18|     346|     363|       8
---------------------------------------------------------------------------
  346-  363 (26.01/20.09)	FSDLLM.CPQhrPLVFGLS
  366-  382 (26.49/13.23)	LQTILLcCPS..ALVWHYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     336.35|     109|     233|     216|     335|       9
---------------------------------------------------------------------------
  216-  335 (167.00/138.19)	GSTIGPLPHDVEV....AIRQWDYTEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGVSSHSShvISAQSTSSlPTTPAPQ
  450-  567 (169.35/108.40)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEAADEKGS..IASGSLSA.PSAPIFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.87|      18|      20|    1803|    1820|      11
---------------------------------------------------------------------------
 1726- 1748 (25.27/10.63)	QQSQGMlgqssVHQMTPSSSYGL
 1803- 1820 (36.61/19.29)	QRPSGY.....VHQQAPTYGHGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.03|      13|     231|    1555|    1569|      12
---------------------------------------------------------------------------
  677-  689 (24.31/ 7.24)	EDMEKPDFSLFSP
 1557- 1569 (24.71/15.59)	EDEEPPAPTLLEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.96|      22|     231|    1435|    1456|      13
---------------------------------------------------------------------------
 1435- 1456 (39.69/22.98)	GERQSDSLEKVRQLLPLPK.QTR
 1645- 1661 (19.74/ 7.02)	..RQG.SIGLYTQNQPLPA.G..
 1662- 1681 (32.53/17.25)	GPR.VDPYRPVR..LPMQKlPTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.81|      15|      23|    1362|    1384|      14
---------------------------------------------------------------------------
 1356- 1370 (25.07/ 7.67)	TVQRSTQQTTEWAML
 1379- 1393 (24.74/24.75)	TVDMQSNNELFTTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      11|      22|    1075|    1085|      16
---------------------------------------------------------------------------
 1075- 1085 (21.19/12.92)	AILCAELTGYC
 1098- 1108 (22.77/14.48)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.45|      18|      23|    1297|    1319|      21
---------------------------------------------------------------------------
 1297- 1319 (27.20/23.79)	LKSL.CE.....DSNDLQDPvlssaQAQR
 1320- 1343 (25.25/11.61)	LMQLiCYphrllDNEDGENP.....QRQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.41|      26|     202|     912|     939|      22
---------------------------------------------------------------------------
  912-  939 (39.83/38.82)	SDLVGSYTTSLClCIVAVLRHYHaCLIL
  941-  957 (21.66/10.94)	QDQMAQVFEGLC....GVVKH.......
 1120- 1143 (39.92/28.06)	SDL..SFHDSLA.TFVAILIARQ.CLLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.56|      25|      25|    1160|    1184|      23
---------------------------------------------------------------------------
 1160- 1184 (44.13/26.40)	CSEQDSEPGARLTCRILLHLFKTPQ
 1188- 1212 (43.43/25.86)	CQSDGNKPTVGIRSSCDRHLLAASQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18316 with Med12 domain of Kingdom Metazoa
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