<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18278

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGNADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length1809
PositionKinase
OrganismColobus angolensis palliatus (Peters' Angolan colobus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Colobus.
Aromaticity0.07
Grand average of hydropathy-0.418
Instability index53.36
Isoelectric point7.62
Molecular weight203777.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18278
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     159.21|      29|     150|     753|     781|       1
---------------------------------------------------------------------------
  753-  781 (50.37/25.60)	CL..ILNPDQTAQVFEG...L...CGVVKHV..V.NPSEC
  902-  931 (38.39/17.91)	CT..VLSSEWLG.VLKA...L...CCSSNHVwgF.NDVLC
  943-  969 (23.42/ 8.31)	SLatFIAILIARQCF.S...L...EDVVQHV..A.LP...
  970- 1001 (25.53/ 9.66)	SL..LAAACGDADAEPGarmT...CRLLLHL..FrAPQA.
 1002- 1022 (21.50/ 7.07)	CF..L..PQATGKPFPG...IrssCD..RH..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.49|      49|     150|    1605|    1656|       2
---------------------------------------------------------------------------
   27-   61 (27.65/ 8.72)	...................QDPKQKEDELTavnvkqgfnNQPAFTGDE....HGSARN
 1605- 1634 (35.10/13.14)	...................QEPERKSAELS.........DQGKTTTDEEKKTKGRKRK
 1638- 1656 (19.10/ 6.71)	SSRVDEYPQSNIYRVPPNY.......................................
 1660- 1704 (75.63/34.83)	SSQMMHHPQSTLWGYNLVGQ.PQQPGFFLQ.........NQSLTPGGSRLDPAGS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.73|      19|      29|    1742|    1770|       4
---------------------------------------------------------------------------
 1752- 1770 (35.69/35.24)	QR.........LLRQAQTRPFQQFPRQG
 1772- 1799 (26.04/ 6.11)	QQtqqqqqtaaLVRQLQKQLSSNQPQQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.29|      12|      29|     592|     603|       5
---------------------------------------------------------------------------
  592-  603 (22.36/16.52)	GVGKERDEARHQ
  624-  635 (21.93/16.03)	GVGDEGQKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     251.21|      96|     732|     366|     514|       6
---------------------------------------------------------------------------
  350-  448 (150.76/90.29)	ANQNKDNQEVAPNDEAVVTLLCEWAVSCKRS....GKHRAMAVAKLLeKRQAEIE....AERC....GESEVLDEKESIssSSLAGSSLPVF.QNVLLRFLDTQAPSLSDPN
  499-  548 (51.13/94.49)	AGENADEHYSKDHDVKMEIFSPMPGESCENAntslGRRMSVNCEKLV.KRE.............................................................
 1184- 1244 (49.32/11.94)	.................................................RQSWLElqlmIKQClkdpGSGSVAEMNNLL..DNIAKATIEVFqQSADLNNSSNSGMSLFNPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.69|      23|      24|    1378|    1401|       8
---------------------------------------------------------------------------
 1378- 1401 (36.35/30.00)	ALQLrLNLV.GGMFDTVQRSTQWTT
 1404- 1427 (34.34/22.63)	ALLL.LQIItSGTVDMHTNNELFTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.25|      58|     156|    1270|    1334|      10
---------------------------------------------------------------------------
 1270- 1330 (88.40/76.61)	GVWLVAPLIARLPTSVQGRVlkaAG.EELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSL
 1433- 1487 (81.50/61.19)	GVLINGTLASDLSNASPG......G.SEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPL
 1493- 1530 (39.34/34.57)	DVITCEPM.GSLIDTKGNKI...AGfDSIDKKQGLQVSTKQK....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.11|      10|      18|    1071|    1081|      11
---------------------------------------------------------------------------
 1071- 1081 (16.69/15.59)	CdGNADDIWTA
 1088- 1097 (18.42/10.86)	C.GKSISIETA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18278 with Med12 domain of Kingdom Metazoa
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