<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18269
Description |
Mediator complex subunit 14 |
Sequence | MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLMPRNPCLFPKIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPGHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSVHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1431 |
Position | Tail |
Organism | Colobus angolensis palliatus (Peters' Angolan colobus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Colobinae> Colobus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.195 |
Instability index | 52.62 |
Isoelectric point | 9.05 |
Molecular weight | 157864.55 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18269
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 109.50| 24| 35| 993| 1017| 1
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993- 1016 (48.34/22.34) SGAYPLTSP.PTSYHSTVNQSPSMM
1031- 1050 (28.16/ 6.67) SGA..LRAPsPASF...VPTPPPSS
1083- 1104 (33.00/11.55) AGNWP.GSP.QVSGPSPAARMPGM.
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 321.52| 95| 508| 259| 356| 3
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169- 236 (78.38/49.00) ......................................................LH.Q..LNQILRHR...LVTTD..LPPQLANLTVANGRV...KFRVEGEFEA..TLTVMGDDPDV..PwrllkLEILVEDKET
259- 356 (159.47/118.92) LFA.DEKPLQDMYNCLHSF...........................CLSLQLEvLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTIKIDENDVskP.....LQIFHDPPLP
382- 492 (83.67/52.58) VHArAHQKLQELKAILRGFnanenssietalpalvvpilepcgnseCLHIFVD.LHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTI.........................
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.71| 10| 118| 120| 129| 4
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120- 129 (18.81/10.35) ALVHARLPSF
241- 250 (18.89/10.43) ALVHSMQISF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 169.93| 51| 397| 932| 990| 5
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932- 990 (86.77/74.03) PAPGLKTFLNMFVdsnQDARRRSVneddnPPS.......PIGGDMMDSLISQLQPPPQQQPFPKQP
1332- 1389 (83.16/52.25) PAVVLKSKMLFFL...QLTQKTSV.....PPQepvsiivPIIYDMASGTTQQADIPRQQNSSVAAP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 134.16| 40| 504| 627| 670| 6
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627- 669 (67.47/53.40) TNMPFVGlrlELSNLEIPHQGVQVEGDGFSHAIRL....LKIPPCKG
693- 736 (66.69/40.16) NNRTWVA...ELVFANCPLNGTSTREQGPSRHVYLtyenLLSEPVGG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 101.28| 33| 40| 1198| 1237| 7
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1198- 1235 (50.65/45.31) QRIIQQETLQLINSNEPGVI..MFKTdalkcRVALSP.KTN
1239- 1274 (50.63/27.06) QLKVTPENAGQWKPDELQVLekFFET.....RVAGPPfKAN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 100.17| 19| 33| 1131| 1149| 8
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28- 40 (19.79/ 6.90) .PA...............PPP...P..GAAVAAA
41- 58 (23.26/ 9.75) AAAAaS............PGYRLMP..RN..PCL
1131- 1149 (37.14/21.16) MPTN.M............PPPRKLP..QRSWAAS
1150- 1182 (19.99/ 7.06) IPTI.LthsalnilllpsPTPGLVPglAGSYLCS
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