<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18245

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVVCVVDISLESVGFMEKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEGTAFPLICLQEDGNLLFYLKFNYLYSYFIVCFCCVIHKRLTILSAIAMLTLLSSLSCRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSLSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMTSSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1575
PositionMiddle
OrganismColobus angolensis palliatus (Peters' Angolan colobus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Colobus.
Aromaticity0.05
Grand average of hydropathy-0.630
Instability index53.00
Isoelectric point8.97
Molecular weight167948.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18245
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     285.05|      41|      41|     959|     999|       2
---------------------------------------------------------------------------
  584-  628 (43.98/13.28)	GHGEdfSKVS.QNPILTSllqiTGNGGS.TIGSSPTP............PHHTP...PPVS...S
  720-  759 (41.98/12.20)	VNMT..AD.TLDTPHITP....APSQCSTPPTTYPQP............VPHPQ...PSIQ...R
  943-  968 (30.41/ 6.01)	HHSG..SQGPLLTTG...................DLG............KEKTQ...KRVK...E
  969- 1012 (59.18/21.41)	GNGT..SNSTLAGPGLDS....KPGKRSRTPSNDGKS............KDKPP...KRKKadtE
 1013- 1068 (38.27/10.22)	GKSP..SHSSSNRPFTPP....TSTGGSKSPGSSGRSqtppgvatppipKITIQipkGTVM...V
 1069- 1112 (33.82/ 7.83)	GKPS..SHSQYTSSGSVS....SSGSKSHHSHSSSSS...........sSASTS...GKMK.ssK
 1133- 1169 (37.42/ 9.76)	GSSL..SKNSSQSGG.......KPG..SSPITKHGLS............SGSSS...TKMK..pQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     336.06|      49|      49|    1188|    1236|       3
---------------------------------------------------------------------------
  766-  818 (53.23/12.74)	.............SDSIGPDVTDILSD...........IA...EE....ASKLPS...TSDD.CPAIgtplrD.SSSSGHSQSTLFDSD
 1188- 1235 (83.66/23.82)	.............SHSRPPGGSDKLAS...........PM...KP....VPGTPP...SSKA.KSPI.....S.SGSGGSHMSGTSSSS
 1236- 1270 (45.03/ 9.75)	G.........mksSSGLGSSGS..LSQ...........K.............TPP...SSNS.CTAS.....S.S.........SFSSS
 1313- 1341 (36.77/ 6.74)	..................PGGEDPLDG...........QM...........G..............V.....S.TNSSSHPMSSKHNMS
 1342- 1376 (40.23/ 8.00)	G............GEFQGKRE......................K..............SDKD.KSKV.....StSGSSVDSSKKTSESK
 1377- 1445 (38.15/ 7.24)	NvgstgvakiiisKHD...GGSPSIKA...........KVtlqKPgessGEGLRPqmtSSKNyGSPL.....I.SGSTPKHERGSPSHS
 1479- 1544 (38.99/ 7.55)	G..irplpeysteKHKKHKKEKKKVKDkdrdrdrdkdrDK...KK....SHSIKP...ESWS.KSPI.....S.SDQSLSMTSNT....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.77|      27|      30|     331|     357|       4
---------------------------------------------------------------------------
  290-  313 (37.84/18.87)	.PSF.SSITSANSVDLPACFFL.KF...PQ
  331-  357 (49.05/26.53)	IPLFETQPTYAPLYELITQFELSKD...PD
  359-  388 (46.87/25.04)	IPLNHNMRFYAALPGQQHCYFLNKDaplPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.60|      19|      22|     826|     844|       5
---------------------------------------------------------------------------
  826-  844 (33.67/19.07)	ENP....YTDPADLIADAAGSPS
  846-  868 (28.93/15.28)	DSPtnhfFHDGVDFNPDLLNSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.03|      17|      20|     535|     552|       6
---------------------------------------------------------------------------
  535-  552 (30.58/19.77)	PPASSPGYGMTTGNNpMS
  557-  573 (34.45/17.42)	PTNTFPGGPITTLFN.MS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.24|      48|     164|      52|     108|       7
---------------------------------------------------------------------------
   52-  108 (65.37/74.65)	SGGH....QHLVSCLETLQKalKVTSlPAMTDRlESIARQNGLGSHLSASGtecyiTSDMF
  219-  270 (78.87/55.83)	SGGHlmnlKYYVSPSDLLDD..KTAS.PIILHE.NNVSRSLGMNASVTIEG.....TSAMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.92|      17|      66|     411|     428|       8
---------------------------------------------------------------------------
  411-  427 (29.86/24.93)	ILNLIRHQVA..YNTLIGS
  639-  657 (26.06/13.38)	LMNLLKDNPAqdFSTLYGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.15|      16|      20|     884|     899|       9
---------------------------------------------------------------------------
  884-  899 (28.64/22.93)	GDNDDFKGFASQALNT
  907-  922 (28.52/22.79)	GDNGETKFKANNQADT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.16|      15|      42|     428|     445|      11
---------------------------------------------------------------------------
  428-  445 (24.28/23.99)	CV..KR.TILkegTAFPLICL
  470-  487 (17.88/ 8.74)	CVihKRlTIL...SAIAMLTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18245 with Med1 domain of Kingdom Metazoa
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