<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18228

Description Mediator of RNA polymerase II transcription subunit 1
SequenceLSLLKLQKLEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRACVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPATYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSSSQGPLLATGDLGKEKTQKRVKEGSGTNNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGCDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSSMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTVLSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1547
PositionMiddle
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.04
Grand average of hydropathy-0.659
Instability index54.03
Isoelectric point8.86
Molecular weight164407.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18228
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     398.25|      50|      51|    1046|    1095|       1
---------------------------------------------------------------------------
  946-  992 (57.57/13.03)	STLSG........PGLDSKPG.KR....SRTPSNDG.......KSKDKP..PKRKKADTEGK.SPSHSSS
  997- 1044 (46.48/ 8.98)	TPPTS........TG.....G.SK.SPGSSGRSQTP.......PGVATPpiPKITIQIPKGTvMVGKPSS
 1046- 1095 (84.11/22.74)	SQYTS........SGSVSSSG.SK.SHHSHSSSSSS.......SSASTS..GKMKSSKSEGS.SSSKLSS
 1096- 1146 (49.55/10.10)	SIYSS........QGS.SGSGqSKnSSQSGGKPGSSpitkhglSSSSSS..TKM...KPQG.....KPSS
 1149- 1189 (53.74/11.63)	NPSLS........KPNISPS.......HSRPPGGCD.......KLASP.....MKPVPG.TP.PSSKAKS
 1231- 1278 (57.77/13.11)	SCTAS........SSSFSSSG.SS.MSSSQNQHGSS.......KGKSPS..RNKKPSLT..A.VIDKLKH
 1279- 1336 (49.01/ 9.90)	GVVTSgpggedpmDGQMGVST.NS.SSHPMSSKHNM.......SGGEFQ..GKREKSDKDKS.KVSTSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     259.39|      50|      50|     289|     338|       2
---------------------------------------------------------------------------
  190-  230 (29.66/12.16)	................YVSPS.DLLD....DKTASPIILHENnvsrslgM...............NA...SVTIEGTSAM
  237-  282 (50.32/26.38)	....PLIMgSHPVdnkWTPSF.SSIT....SANSVDLPACFF.......L...............KF...PQPIPVSRAC
  289-  338 (91.46/54.70)	CTGIPLFE.TQPT...YVPLY.ELITQFELSKDPDPIPLNHN.......M...............RF...YAALPGQQHC
  348-  389 (35.62/16.27)	...........PD...GRSLQgTLVSKITF.QHPGRVPLILN.......L..............iRHqvaYNTLIGS..C
  399-  454 (52.33/27.77)	SPGLLQFE.V.......CPLS.E..SRFSVSFQH...PVNDS.......LvcvvmdvqdsthvscKL...YKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.76|      18|      20|     506|     523|       4
---------------------------------------------------------------------------
  506-  523 (36.73/15.71)	PPASSPGYGMTTGNNPMS
  528-  544 (27.16/ 9.56)	PTNTFPGGPITTLFN.MS
  594-  609 (22.25/ 6.40)	PPPVSSMAG.NTKNHPM.
  636-  653 (23.61/ 7.28)	SSSGSPRMEICSGSNKTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.24|      16|      64|    1369|    1389|       5
---------------------------------------------------------------------------
 1356- 1371 (25.11/ 7.80)	AKIIISK.....HDGGSPSIK
 1372- 1392 (18.13/14.42)	AKVTLQKpgessGEGLRPQMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.90|      16|      17|    1457|    1472|       6
---------------------------------------------------------------------------
 1457- 1472 (25.78/19.08)	EYSTEKHKKHKKEKKK
 1475- 1490 (26.12/19.44)	DKDRDRDRDKDRDKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.26|      29|      49|     855|     884|       7
---------------------------------------------------------------------------
  855-  884 (48.04/31.33)	GD....NDDFKGFASQAlNTLGVPMLGGDNGETK
  885-  902 (21.76/ 8.06)	.........FKG.NSQA.DTVDFSIIS.....VA
  903-  932 (36.46/18.69)	GKalgpADLMEHHSSSQ....GPLLATGDLGKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.99|      68|      97|     655|     723|       8
---------------------------------------------------------------------------
  548-  592 (63.95/26.75)	............KDRH....ESVGHGEDFS.KV.SQNPILTslLQITGNGGST.......IGSSP......TPP.......HH
  655-  723 (124.26/63.37)	KKSSRLP...PDKPKHQT..EDDFQRELFSMDVDSQNPIFD..VNMTADTLDT.....PHITPAP..SQCSTPPATyPQPVPH
  753-  822 (76.78/33.72)	EEASKLPstsDDCPAIGTplRDS......SSSGHSQSTLFD......SDVFQTnnnenPYTDPADliADAAGSPSS.DSPTNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     134.99|      30|      81|    1417|    1446|       9
---------------------------------------------------------------------------
 1190- 1219 (35.00/ 9.40)	...PISSGSGGSHMSGTSSSSSMKSSSglgSSG
 1417- 1446 (50.20/16.67)	SKSPAYTPQNLDSESESGSSIAEKSYQ...NSP
 1500- 1528 (49.78/16.47)	SKSPISSDQSLSMTSNTVLS.ADRPSR...LSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18228 with Med1 domain of Kingdom Metazoa
Unable to open file!