<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18221

Description Mediator complex subunit 12
SequenceFASPALLSHHLPLRKTKLNDAFLPQDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSIERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKRQAQGRIKLGRRRNDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSMEWGRGGRQGMAP
Length2094
PositionKinase
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.466
Instability index55.11
Isoelectric point6.88
Molecular weight232573.38
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18221
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.34|      14|      15|    2008|    2022|       1
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 1861- 1874 (24.89/ 7.72)	RQQQPAVPQ.GQRLR
 2014- 2028 (25.45/13.97)	QQQQQQQQQqQQQQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.61|      15|      16|    2036|    2050|       3
---------------------------------------------------------------------------
 2036- 2050 (29.50/16.52)	QQQQQQAAPPQPQPQ
 2052- 2066 (27.11/14.41)	QPQVAAGLQPQAQGQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.37|      16|      17|    1754|    1769|       4
---------------------------------------------------------------------------
 1727- 1739 (19.66/ 7.02)	..EP...PKTDK..PGAAPP
 1754- 1769 (31.73/16.79)	RSQP..ATKTED..YGMGPG
 1770- 1789 (20.98/ 8.09)	RSGPygVTVPPDllHHPNPG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.33|      21|      21|    1908|    1928|       5
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 1911- 1931 (42.64/24.48)	SHVGLQQH..TGPAGTMV.........PPSYS
 1932- 1961 (21.70/ 8.21)	SQPYQSTHpsTNP..TLVdptrhlqqrPSGYV
 1979- 1994 (25.99/11.55)	SHQTLQQ...TPMISTMT.........P....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     745.91|     214|     231|     342|     570|       6
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  209-  338 (126.90/59.54)	......................................................................................................................GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STP
  342-  570 (332.23/211.51)	LLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS..FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ
  573-  806 (286.78/152.16)	MLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.71|      16|      20|    1620|    1639|       7
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 1620- 1639 (15.40/23.38)	IDTKgNKIAGFDsIFkkEGL
 1641- 1656 (30.31/18.62)	VSTK.QKLSPWD.LF..EGL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.42|      18|      21|    1796|    1815|      10
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 1796- 1815 (29.65/24.04)	YRqgSIGLYTQNQPLPAGGP
 1820- 1837 (35.77/21.68)	YR..PVRLPMQKLPTRPTYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     389.50|      90|     151|    1099|    1188|      12
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 1099- 1188 (152.37/105.45)	GTCGFNDLLCNVDVSDLSFHDSLATFVAILIA...RQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKT.PQLNPCQSDGNKP
 1250- 1332 (132.75/90.69)	GSGGRRQGGRNISVETASL.DVYAKYVLRSIC...QQEWVGE...RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICY.PHRLLDNEDGENP
 1333- 1417 (104.37/69.34)	QRQRIKRILQNLDQWTMR.QSSLELQLMIKQTpnnEMNSLLENIAK.ATIEVFQQSA..ETGSSSGN..TASNMPSSSKTkPVLSSIERSG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      21|      23|    1514|    1536|      13
---------------------------------------------------------------------------
 1514- 1536 (31.02/33.84)	QQTTewAVL.LLEIIISGTV..DMQS
 1539- 1562 (27.14/19.24)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.20|      24|     152|     915|     945|      15
---------------------------------------------------------------------------
  917-  945 (32.25/43.76)	LCivAVLRHYhaCLILNQDQMAqVFEGLC
 1070- 1093 (44.95/26.63)	LC..AELTGY..CKSLSAEWLG.VLKALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.36|      19|      21|    1446|    1465|      18
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 1446- 1465 (28.93/21.96)	KGQ.HLGsSSRKER..DRQKQKR
 1468- 1489 (26.43/14.50)	QGRiKLG.RRRNDQylDDCKPKQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18221 with Med12 domain of Kingdom Metazoa
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