<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18219

Description Mediator complex subunit 12
SequenceFASPALLSHHLPLRKTKLNDAFLPQDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSIERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKRGRKERRQAQGRIKLGRRRSIIGKSLNCMFYFHLTDLLWPWQVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSMEWGRGGRQGMAP
Length2145
PositionKinase
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.499
Instability index57.85
Isoelectric point7.31
Molecular weight239030.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18219
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     167.42|      16|      16|    2021|    2036|       1
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 2021- 2036 (37.98/15.44)	QQQQQQQQ....QQQQQQQQ
 2050- 2065 (34.20/13.20)	QQQQQQIL....RQQQQQQQ
 2066- 2081 (37.98/15.44)	QQQQQQQQ....QQQQQQQQ
 2082- 2097 (33.40/12.73)	QQQHQQQQ....QQQAAPPQ
 2098- 2117 (23.87/ 7.10)	PQPQSQPQvaagLQPQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     742.38|     216|     230|     342|     570|       2
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  209-  433 (276.08/201.48)	.........GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS
  434-  666 (328.94/212.52)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSS
  669-  806 (137.36/78.10)	FEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ............................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1020|    1032|       3
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 1020- 1032 (25.11/17.34)	ENPAA.HTFTYTGL
 1038- 1051 (21.03/13.14)	ENPANrYSFVCNAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     399.87|     102|     148|    1660|    1791|       4
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 1660- 1791 (154.25/129.37)	GL.KPSAPLSWGwfGTvRVDrrvargeeQQrlllyHTHlrP.RPRAYYLEPLPLPPEDEEPPA........PTL......LEPEKKAPEPPKTDKPGAAPpsteerkkksTKGKK.RSQPATKTEDYG.........MGPGRSGPYGVTVPPDllHHP
 1807- 1916 (130.84/63.98)	GLyTQNQPLPAG..GP.RVD....................PyRPVRLPMQKLPTRP..TYPGV.......lPTTmtgvmgLEPSSYKTSVYRQQQP.AVP...........QGQRlRQQLQAKIQSQGmlgqssvhqMTP..SSSYGLQTSQG..YTP
 1922- 2002 (114.78/54.63)	GL..........................QQ.....HTG.....PAGTMV.....PPSYSSQPYqsthpstnPTL......VDPTRHLQQRPSGYVHQQAP..........TYG.....HGLTSTQRFS.........HQTLQQTPMISTMTP......
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.17|      47|     231|    1238|    1284|       5
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 1057- 1085 (32.14/14.45)	...............GHHDPDRvnDIAILCAEL.TGYCKSL.....SAEW
 1087- 1132 (62.91/35.81)	GVLKALCCSSNNGTCGFNDLLC..NVDVSDLSFhDSLATFVAILIARQ..
 1238- 1284 (81.12/48.46)	GTEELPEEEGGGGSGGRRQGGR..NISVETASL.DVYAKYVLRSICQQEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      59|    1370|    1393|       6
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 1370- 1393 (38.04/22.08)	SLLENIAKATIEVFQQSAETGSSS
 1431- 1454 (39.88/23.50)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.37|      46|     202|     929|     981|       7
---------------------------------------------------------------------------
  929-  981 (73.87/59.42)	CLILnQDQMAqvfeglCGVVKHGMN....RSDGSSAER..C.ILAYLYDL..YTSCSHLKNK
 1133- 1187 (63.49/35.97)	CLLL.EDLIR......CAAIPSLLNaacsEQDSEPGARltCrILLHLFKTpqLNPCQSDGNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.72|      18|      21|    1518|    1536|       8
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 1519- 1536 (31.38/21.47)	QQTTEW..AVL.LLEIIISGT
 1540- 1560 (21.34/ 7.42)	QSNNELftTVLdMLSVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      18|     852|     868|      10
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  856-  868 (24.86/25.49)	MSYHLPLVQHVQF
  873-  885 (22.52/ 8.72)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      18|    1321|    1335|      11
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 1321- 1335 (21.57/18.67)	HRLLDNEDgENPQRQ
 1338- 1351 (26.45/16.97)	KRILQNLD.QWTMRQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.98|      16|      18|    1622|    1639|      13
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 1622- 1639 (19.28/20.55)	GSLIDTKgNKIAGFDsIF
 1643- 1658 (29.70/18.51)	GLQVSTK.QKLSPWD.LF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18219 with Med12 domain of Kingdom Metazoa
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