<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18219

Description Mediator complex subunit 12
SequenceFASPALLSHHLPLRKTKLNDAFLPQDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSIERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKRGRKERRQAQGRIKLGRRRSIIGKSLNCMFYFHLTDLLWPWQVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSMEWGRGGRQGMAP
Length2145
PositionKinase
OrganismAotus nancymaae (Ma's night monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Aotidae> Aotus.
Aromaticity0.07
Grand average of hydropathy-0.499
Instability index57.85
Isoelectric point7.31
Molecular weight239030.41
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18219
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     167.42|      16|      16|    2021|    2036|       1
---------------------------------------------------------------------------
 2021- 2036 (37.98/15.44)	QQQQQQQQ....QQQQQQQQ
 2050- 2065 (34.20/13.20)	QQQQQQIL....RQQQQQQQ
 2066- 2081 (37.98/15.44)	QQQQQQQQ....QQQQQQQQ
 2082- 2097 (33.40/12.73)	QQQHQQQQ....QQQAAPPQ
 2098- 2117 (23.87/ 7.10)	PQPQSQPQvaagLQPQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     742.38|     216|     230|     342|     570|       2
---------------------------------------------------------------------------
  209-  433 (276.08/201.48)	.........GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS
  434-  666 (328.94/212.52)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSS
  669-  806 (137.36/78.10)	FEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1020|    1032|       3
---------------------------------------------------------------------------
 1020- 1032 (25.11/17.34)	ENPAA.HTFTYTGL
 1038- 1051 (21.03/13.14)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     399.87|     102|     148|    1660|    1791|       4
---------------------------------------------------------------------------
 1660- 1791 (154.25/129.37)	GL.KPSAPLSWGwfGTvRVDrrvargeeQQrlllyHTHlrP.RPRAYYLEPLPLPPEDEEPPA........PTL......LEPEKKAPEPPKTDKPGAAPpsteerkkksTKGKK.RSQPATKTEDYG.........MGPGRSGPYGVTVPPDllHHP
 1807- 1916 (130.84/63.98)	GLyTQNQPLPAG..GP.RVD....................PyRPVRLPMQKLPTRP..TYPGV.......lPTTmtgvmgLEPSSYKTSVYRQQQP.AVP...........QGQRlRQQLQAKIQSQGmlgqssvhqMTP..SSSYGLQTSQG..YTP
 1922- 2002 (114.78/54.63)	GL..........................QQ.....HTG.....PAGTMV.....PPSYSSQPYqsthpstnPTL......VDPTRHLQQRPSGYVHQQAP..........TYG.....HGLTSTQRFS.........HQTLQQTPMISTMTP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.17|      47|     231|    1238|    1284|       5
---------------------------------------------------------------------------
 1057- 1085 (32.14/14.45)	...............GHHDPDRvnDIAILCAEL.TGYCKSL.....SAEW
 1087- 1132 (62.91/35.81)	GVLKALCCSSNNGTCGFNDLLC..NVDVSDLSFhDSLATFVAILIARQ..
 1238- 1284 (81.12/48.46)	GTEELPEEEGGGGSGGRRQGGR..NISVETASL.DVYAKYVLRSICQQEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      59|    1370|    1393|       6
---------------------------------------------------------------------------
 1370- 1393 (38.04/22.08)	SLLENIAKATIEVFQQSAETGSSS
 1431- 1454 (39.88/23.50)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.37|      46|     202|     929|     981|       7
---------------------------------------------------------------------------
  929-  981 (73.87/59.42)	CLILnQDQMAqvfeglCGVVKHGMN....RSDGSSAER..C.ILAYLYDL..YTSCSHLKNK
 1133- 1187 (63.49/35.97)	CLLL.EDLIR......CAAIPSLLNaacsEQDSEPGARltCrILLHLFKTpqLNPCQSDGNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.72|      18|      21|    1518|    1536|       8
---------------------------------------------------------------------------
 1519- 1536 (31.38/21.47)	QQTTEW..AVL.LLEIIISGT
 1540- 1560 (21.34/ 7.42)	QSNNELftTVLdMLSVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.38|      13|      18|     852|     868|      10
---------------------------------------------------------------------------
  856-  868 (24.86/25.49)	MSYHLPLVQHVQF
  873-  885 (22.52/ 8.72)	MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      18|    1321|    1335|      11
---------------------------------------------------------------------------
 1321- 1335 (21.57/18.67)	HRLLDNEDgENPQRQ
 1338- 1351 (26.45/16.97)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.98|      16|      18|    1622|    1639|      13
---------------------------------------------------------------------------
 1622- 1639 (19.28/20.55)	GSLIDTKgNKIAGFDsIF
 1643- 1658 (29.70/18.51)	GLQVSTK.QKLSPWD.LF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18219 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELEKGQHLGSSSRKERDRQKQKRGRKERRQAQ
2) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
3) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQ
5) QQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPVNWVGDSMEWGRGGRQGMAP
6) RAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
1443
680
620
1855
2074
1702
1474
719
667
2045
2145
1853










Molecular Recognition Features






MoRF SequenceStartStop




1) QQYHIRQQQQQQILRQQQQQQQQQQQ
2044
2069